Preclinical only, no clinical indication yet

By indication / Preclinical only, no clinical indication yet

37 imaging agents and 141 therapeutic agents reported for this indication. Stage reflects how far each has been taken, not what is available in any given country.

Imaging

Agent	Isotope	Stage	Syntheses
[68Ga]Ga-BPAMD paired with [161Tb]Tb-BPAMD	Ga-68	—	6
[68Ga]Ga-TRAP-(RGD)3	Ga-68	—	4
[11C]L-glutamine	C-11	—	2
[18F]AlF-3p-C-NETA-TATE	F-18	preclinical study	2
[18F]fluoroacetate	F-18	—	2
[18F]F-PSMA-617-NODA	F-18	—	2
[18F]F-PSMA-617-RESCA	F-18	—	2
[68Ga]Ga-DOTA-r-a-ABA-CPCR4 paired with [177Lu]Lu-DOTA-r-a-ABA-CPCR4	Ga-68	preclinical study	2
[18F]BPAM121	F-18	Research	1
[18F]TTCO-IL2	F-18	Research	1
[11C]PK68	C-11	—	1
[11C]PS13	C-11	first-in-human	1
[18F]ADPM06	F-18	—	1
[18F]AG-120	F-18	preclinical study	1
[18F]AQ28A	F-18	preclinical	1
[18F]EKZ-001	F-18	preclinical (supporting first-in-human translation)	1
[18F]FBAM	F-18	preclinical	1
[18F]FB-S100s	F-18	preclinical	1
[18F]FCPPC	F-18	—	1
[18F]FG-CP31398	F-18	—	1
[18F]FPG-IL4	F-18	—	1
[18F]JMV5763	F-18	—	1
[18F]mBPET-1	F-18	—	1
[18F]MEL050	F-18	phase I	1
[18F]NS10743	F-18	preclinical	1
[68Ga]Ga-NOTA-BBN2	Ga-68	preclinical	1
[89Zr]Zr-TROP2	Zr-89	preclinical	1
[18F]FRPG	F-18	Research
[18F]AlF-OncoFAP-NODAGA paired with [177Lu]Lu-OncoFAP-DOTAGA	F-18	Research
[18F]AlF-OncoFAP-NOTA paired with [177Lu]Lu-OncoFAP-DOTAGA	F-18	Research
[68Ga]Ga-OncoFAP-NODAGA	Ga-68	Research
[68Ga]Ga-OncoFAP-NOTA	Ga-68	Research
[18F]SqFLT	F-18	Research
[18F]FSO3-PSMA	F-18	Research
[18F]ef5	F-18	—
6-[18F]fluoro-3-(pyridin-3-yl)-1H-indole	F-18	preclinical
[68Ga]Ga-DOTA-AMBS-CPCR4	Ga-68	—

Therapy

Agent	Isotope	Stage	Syntheses
[177Lu]Lu-RM2 paired with [68Ga]Ga-RM2	Lu-177	—	9
[177Lu]Lu-FAPI-2286 paired with [64Cu]Cu-FAPI-2286	Lu-177	—	9
[177Lu]Lu-FAPI paired with [68Ga]Ga-FAPI	Lu-177	—	7
[177Lu]Lu-DOTA-JR11	Lu-177	—	6
[177Lu]Lu-FAPI-04 paired with [68Ga]Ga-FAPI-04	Lu-177	—	5
[161Tb]Tb-DOTATATE paired with [68Ga]Ga-DOTATATE	Tb-161	—	4
[212Pb]Pb-TCMC-chOI-1	Pb-212	preclinical study	4
[211At]At-astatobenzoate	At-211	—	3
[177Lu]Lu-DOTA-4AH29	Lu-177	—	3
[177Lu]Lu-DOTA-r-a-ABA-iodoCPCR4 paired with [68Ga]DOTA-r-a-ABA-iodoCPCR4	Lu-177	preclinical study	2
[161Tb]Tb-RM2 paired with [68Ga]Ga-RM2	Tb-161	preclinical study	2
[161Tb]Tb-AMTG	Tb-161	preclinical study	2
[225Ac]Ac-DOTA-4AH29	Ac-225	—	2
[67Cu]Cu-SARTATE paired with [64Cu]Cu-sartate	Cu-67	preclinical study	2
[131I]I-GMIB-4AH29	I-131	—	2
[90Y]Y-90-ITGA6B4	Y-90	—	2
[177Lu]Lu-DOTA-r-a-ABA-CPCR4 paired with [68Ga]Ga-DOTA-r-a-ABA-CPCR4	Lu-177	—	2
[89Zr]DFO-F8	Zr-89	Reported once	2
[177Lu]Lu-pepa-pic2-C-Hex-KuE	Lu-177	Reported once	2
[68Ga]AAZTA-FAPI-46	Ga-68	preclinical study	2
[68Ga]NOTA-MI-exendin-4	Ga-68	Reported once	2
[177Lu]Lu-6R-RedFol-1	Lu-177	Reported once	2
[68Ga]DOTA-r-a-ABA-iodoCPCR4 paired with [177Lu]Lu-DOTA-r-a-ABA-iodoCPCR4	Ga-68	preclinical study	2
[111In]pb12	In-111	Reported once	2
[177Lu]Lu-DOTA-rhCCK-18	Lu-177	—	1
[161Tb]Tb-3p-C-NETA paired with [68Ga]Ga-3p-C-NETA	Tb-161	—	1
[47Sc]Sc-PSMA-617 paired with [111In]In-PSMA-617	Sc-47	preclinical study	1
[212Pb]Pb-FAPI-46 paired with [68Ga]Ga-FAPI-46	Pb-212	—	1
[90Y]Y-90-NM600	Y-90	—	1
[177Lu]Lu-DOTA-exendin-4 paired with [68Ga]Ga-DOTA-exendin-4	Lu-177	—	1
[177Lu]Lu-satoreotide	Lu-177	—	1
[177Lu]Lu-DOTA-NI-FAPI-04	Lu-177	preclinical	1
[188Re]Re-188-HYNIC-BBN	Re-188	—	1
[211At]At-astatophenethylsuccinamate	At-211	preclinical	1
[177Lu]Lu-Rituximab	Lu-177	—	1
[177Lu]Lu-BL02	Lu-177	preclinical study	1
[89Zr]DFO-Per-F(ab')2	Zr-89	Reported once	1
[131I]I-Tyr-d-peptide-PEG11-Tz	I-131	Reported once	1
[68Ga]PEG2-COU	Ga-68	Reported once	1
[68Ga]PEG6-COU	Ga-68	Reported once	1
[131I]I-BNF03	I-131	Reported once	1
[131I]I-WS03	I-131	Reported once	1
[99mTc]N4-CCK-66	Tc-99m	Reported once	1
[67Ga]Comb-2	Ga-67	Reported once	1
[177Lu]Lu-Comb-2	Lu-177	Reported once	1
[177Lu]Lu-DOTA-ABDB6	Lu-177	Reported once	1
[225Ac]Ac-Macropa-pertuzumab-PEG6-DM1	Ac-225	preclinical study	1
[225Ac]Ac-DOTA-MSC3 paired with [111In]DOTA-MSC3	Ac-225	preclinical study	1
[111In]DOTA-MSC3 paired with [225Ac]Ac-DOTA-MSC3	In-111	Reported once	1
[177Lu]Lu-DOTA-KiSS-34 paired with [68Ga]DOTA-KiSS-34	Lu-177	preclinical study	1
[68Ga]DOTA-KiSS-34 paired with [177Lu]Lu-DOTA-KiSS-34	Ga-68	Reported once	1
[68Ga]PKB2	Ga-68	Reported once	1
[177Lu]Lu-BL34 paired with [68Ga]BL34	Lu-177	preclinical study	1
[64Cu]SarAr-PEG10-Tz paired with [67Cu]Cu-SarAr-PEG10-Tz	Cu-64	Reported once	1
[89Zr]DFO-11E10C11	Zr-89	Reported once	1
[177Lu]Lu-DOTA-11E10C11	Lu-177	Reported once	1
[177Lu]Lu-DOTA-GA4	Lu-177	preclinical study	1
[177Lu]Lu-DOTA-GA13	Lu-177	Reported once	1
[89Zr]Nb159	Zr-89	Reported once	1
[89Zr]PEG-Nb159 paired with [177Lu]Lu-PEG-Nb159	Zr-89	Reported once	1
[177Lu]Lu-PEG-Nb159 paired with [89Zr]PEG-Nb159	Lu-177	preclinical study	1
[225Ac]Ac-3p-C-DEPA-NO2	Ac-225	preclinical study	1
[86Y]pepa-pic2-C-Hex-KuE	Y-86	Reported once	1
[86Y]pepa-pic2	Y-86	Reported once	1
[161Tb]Tb-pepa-pic2-C-Hex-KuE	Tb-161	Reported once	1
[68Ga]NOTA-A1-His	Ga-68	preclinical study	1
[18F]AlF-NOTA-iPD-L1	F-18	Reported once	1
[177Lu]Lu-DOTA-iPD-L1	Lu-177	Reported once	1
[111In]DOTA-TRK-950 paired with [177Lu]Lu-DOTA-TRK-950	In-111	Reported once	1
[177Lu]Lu-cAC10	Lu-177	Reported once	1
[177Lu]Lu-LW01110	Lu-177	Reported once	1
[177Lu]Lu-LW01142	Lu-177	Reported once	1
[111In]DOTAGA-FAP-2286	In-111	Reported once	1
[111In]DOTAGA-FAP-2286-ALB paired with [225Ac]Ac-DOTAGA-FAP-2286-ALB	In-111	preclinical study	1
[225Ac]Ac-DOTAGA-FAP-2286-ALB paired with [111In]DOTAGA-FAP-2286-ALB	Ac-225	Reported once	1
[18F]AlF-H3RESCA-FAPI	F-18	preclinical study	1
[68Ga]LW02060 paired with [177Lu]Lu-LW02060	Ga-68	Reported once	1
[68Ga]LW02080 paired with [177Lu]Lu-LW02080	Ga-68	Reported once	1
[177Lu]Lu-LW02060 paired with [68Ga]LW02060	Lu-177	Reported once	1
[177Lu]Lu-LW02080 paired with [68Ga]LW02080	Lu-177	preclinical study	1
[225Ac]Ac-Macropa-N4MU01	Ac-225	Reported once	1
[68Ga]TATE-46	Ga-68	preclinical study	1
[225Ac]Ac-DOTA-PKU525	Ac-225	Reported once	1
[131I]I-ERIC1	I-131	preclinical study	1
[212Pb]Pb-DOTAM-GRPR1	Pb-212	preclinical study	1
[177Lu]Lu-DOTA-PEG7-tetrazine	Lu-177	preclinical study	1
[68Ga]BCY18469	Ga-68	Reported once	1
[177Lu]Lu-BCY18469	Lu-177	preclinical study	1
[111In]BCY18469	In-111	preclinical study	1
[111In]eFAP-6 paired with [177Lu]Lu-eFAP-6	In-111	Reported once	1
[177Lu]Lu-eFAP-6 paired with [111In]eFAP-6	Lu-177	preclinical study	1
[177Lu]Lu-DOTA-POL3026	Lu-177	Reported once	1
[68Ga]DOTA-FD2 paired with [177Lu]Lu-DOTA-FD2	Ga-68	Reported once	1
[68Ga]DOTA-FD3 paired with [177Lu]Lu-DOTA-FD3	Ga-68	Reported once	1
[177Lu]Lu-DOTA-FD3 paired with [68Ga]DOTA-FD3	Lu-177	Reported once	1
[177Lu]Lu-PEG-(DOTA)1(ACUPA)3	Lu-177	Reported once	1
[111In]AT2S	In-111	Reported once	1
[89Zr]DFO-NY003/	Zr-89	preclinical study	1
[177Lu]Lu-DTPA-NY003	Lu-177	preclinical study	1
[68Ga]HTK03177	Ga-68	Reported once	1
[203Pb]eSOMA-01	Pb-203	Reported once	1
[212Pb]Pb-eSOMA-02	Pb-212	Reported once	1
[177Lu]Lu-3p-C-NETA-ePSMA-16	Lu-177	Reported once	1
[213Bi]Bi-3p-C-NETA-ePSMA-16	Bi-213	Reported once	1
[18F]AlF-3p-C-NETA-ePSMA-16	F-18	Reported once	1
[68Ga]SB02055	Ga-68	preclinical study	1
[68Ga]SB04028	Ga-68	preclinical study	1
[177Lu]Lu-DOTA-MI-exendin-4	Lu-177	Reported once	1
[99mTc]Tc(CO)3-NOTA-PEG2Nle-CycMSHhex	Tc-99m	Reported once	1
[99mTc]Tc(CO)3-NOTA-AocNle-CycMSHhex	Tc-99m	Reported once	1
[68Ga]NOTA-C2	Ga-68	Reported once	1
[68Ga]NOTA-ABDC2	Ga-68	Reported once	1
[177Lu]Lu-DOTA-ABDC2	Lu-177	Reported once	1
[68Ga]TacBOMB2	Ga-68	Reported once	1
[68Ga]TacBOMB3	Ga-68	Reported once	1
[125I]NaIO3	I-125	Reported once	1
[211At]At-NaAtO3	At-211	Reported once	1
[123I]PARPi-01	I-123	preclinical study	1
[68Ga]TacsBOMB3	Ga-68	Reported once	1
[68Ga]TacsBOMB6	Ga-68	Reported once	1
[111In]DO3A-BODIPY-Tz-TCO-trastuzumab	In-111	preclinical study	1
[111In]BQ7859	In-111	Reported once	1
[99mTc]Tc(CO)3-GRGDHV	Tc-99m	Reported once	1
[18F]AlF-NOTA-DV1-k-(DV3)	F-18	Reported once	1
[131I]PN67 paired with [124I]PN67	I-131	Reported once	1
[124I]PN67 paired with [131I]PN67	I-124	Reported once	1
[131I]GV-620	I-131	Reported once	1
[225Ac]Ac-hu5A10	Ac-225	Reported once	1
[131I]I-T-ZHP1	I-131	Reported once	1
[68Ga]177-AAZTA5-PSMA-617 paired with [177Lu]Lu-177-AAZTA5-PSMA-617	Ga-68	Reported once	1
[44Sc]177-AAZTA5-PSMA-617	Sc-44	Reported once	1
[177Lu]Lu-177-AAZTA5-PSMA-617 paired with [68Ga]177-AAZTA5-PSMA-617	Lu-177	Reported once	1
[177Lu]Lu-6S-RedFol-1	Lu-177	Reported once	1
[177Lu]Lu-OxFol-1	Lu-177	Reported once	1
[177Lu]Lu-DOTA-ST8950	Lu-177	Reported once	1
[131I]PSMA-769	I-131	Reported once	1
[64Cu]Pep-1L paired with [225Ac]Ac-Pep-1L	Cu-64	Reported once	1
[177Lu]Lu-OncoFAP-DOTAGA paired with [68Ga]Ga-OncoFAP-DOTAGA	Lu-177	Research
[188Re]Re-RC-160	Re-188	—
[177Lu]Lu-PSMA-617-treated	Lu-177	investigational
[225Ac]Ac-crown-TATE	Ac-225	—

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