Tracer library / [18F]AlF-3p-C-NETA-TATE

[18F]AlF-3p-C-NETA-TATE

Also written as [18F]AlF-3p-C-NETA-TATE; [F-18]AlF-3p-C-NETA-TATE

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 2

Preclinical only, no clinical indication yet

What it is

Compound class: Radiolabeled somatostatin analogue (3p-C-NETA-TATE, chelator-linker-octreotate peptide conjugate)
Target / mechanism: Somatostatin receptor targeting (TATE/octreotate analogue) PMID 35966589
Clinical application: Neuroendocrine tumour (NET) imaging/theranostics PMID 35966589
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
AllinOne (AiO) Trasis	—	HPLC	41.4 ± 8% decay-corrected	>97%	3p-C-NETA-TATE	35966589 2022 Theranostics [18F]AlF-3p-C-NETA-TATE was synthesized in an automated AllinOne® synthesis module (Trasis, Liège, Belgium) - the corresponding [18F]AlF-3p-C-NETA-TATE was obtained in good RCY [(41.4 ± 8%, (decay-corrected, activity final batch of purified product/activity in reactor, n = 8, apparent molar activity 22 ± 8 GBq/μmol)]
AllinOne (AiO) Trasis	—	HPLC	41.4 ± 8% decay-corrected	>97%	3p-C-NETA-TATE	35966589 2022 Theranostics [18F]AlF-3p-C-NETA-TATE was synthesized in an automated AllinOne® synthesis module (Trasis, Liège, Belgium) - [18F]AlF-3p-C-NETA-TATE was obtained in good RCY [(41.4 ± 8%, (decay-corrected, activity final batch of purified product/activity in reactor, n = 8, apparent molar activity 22 ± 8 GBq/μmol)]

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 35966589: '3p-C-NETA-TATE'. Stage set/updated at stage 23 from PMID 35966589: 'In this study we evaluated 3p-C-NETA, as potential theranostic Al18F-chelator and present first results of radiosynthesis and preclinical evaluation of [18F]AlF-3p-C-NETA-TATE.'.