Tracer library / [225Ac]Ac-DOTA-4AH29

[225Ac]Ac-DOTA-4AH29

Also written as [Ac-225]Ac-DOTA-4AH29

Radionuclide: Ac-225 t½ 14284.8 min
Modality: Therapy
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Preclinical only, no clinical indication yet Fibroblast activation / tumour stroma

What it is

Compound class: FAP-targeting single-domain antibody (sdAb) conjugated to DOTA chelator
Target / mechanism: Fibroblast activation protein (FAP)-targeting single-domain antibody PMID 41688618
Clinical application: FAP-positive cancers (targeted radionuclide therapy) PMID 38040444
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	—	—	DOTA-4AH29	41688618 2026 EJNMMI Res sdAb 4AH29 was radiolabeled with 111In, 177Lu, and 225Ac at a selected pH for 30 min at 50 °C, then purified using NAP5 SEC

Need this precursor?We can point you to suppliers for [225Ac]Ac-DOTA-4AH29, or handle the enquiry for you.

Get in touch

Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 3 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41688618: 'DOTA-4AH29'. Stage set/updated at stage 39 from PMID 38040444: 'Preclinical Evaluation of a Radiotheranostic Single-Domain Antibody Against Fibroblast Activation Protein α.'.