Tracers / [131I]PN67
[131I]PN67
Also written as [I-131]PN67
- Radionuclide
- I-131 t½ 11549 min
- Modality
- Therapy
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- γ-secretase inhibitor (Semagacestat-based) small molecule probe
- Target / mechanism
- γ-secretase (Notch pathway regulator) PMID 34475100
- Clinical application
- Imaging of γ-secretase activity in breast cancer and glioblastoma (preclinical mouse models) PMID 34475100
- Theranostic pair
- <a href="/tracers/i124-pn67/">i124-pn67</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | HPLC | >80% | >99% | trimethyl-tin precursor (compound 3) | 34475100 2021 Clin Cancer Res Tin precursor 3 (10 ug) in Eppendorf tube was dissolved in 20ul of methanol and followed by adding a solution of carrier-free [131I]-NaI — recovery yield > 80% |
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Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 34475100. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty.