Tracers / [124I]PN67

[124I]PN67

Also written as [I-124]PN67

Radionuclide: I-124 t½ 6013 min
Modality: Therapy
Production route: —
Stage: Reported once
Syntheses indexed: 1

What it is

Compound class: Radioiodinated γ-secretase inhibitor (Semagacestat-based small molecule)
Target / mechanism: γ-secretase (Notch signaling pathway) inhibitor-based probe PMID 34475100
Clinical application: PET imaging of γ-secretase activity and target engagement of clinical GSIs in tumors (preclinical) PMID 34475100
Theranostic pair: <a href="/tracers/i131-pn67/">i131-pn67</a>

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	HPLC	>80%	>99%	trimethyl-tin precursor (compound 3)	34475100 2021 Clin Cancer Res Tin precursor 3 (10 ug) in Eppendorf tube was dissolved in 20ul of methanol and followed by adding a solution of carrier-free ... [124I]-NaI in 0.1N NaOH — recovery yield > 80%

Need this precursor?We can point you to suppliers for [124I]PN67, or handle the enquiry for you.

Get in touch

Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 34475100. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty.