Tracer library / [124I]PN67
[124I]PN67
Also written as [I-124]PN67
- Radionuclide
- I-124 t½ 6013 min
- Modality
- PET
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- Radioiodinated γ-secretase inhibitor (Semagacestat-based small molecule)
- Target / mechanism
- γ-secretase (Notch signaling pathway) inhibitor-based probe PMID 34475100
- Clinical application
- PET imaging of γ-secretase activity and target engagement of clinical GSIs in tumors (preclinical) PMID 34475100
- Theranostic pair
- [131I]PN67
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | HPLC | >80% | >99% | trimethyl-tin precursor (compound 3) | 34475100 2021 Clin Cancer Res Tin precursor 3 (10 ug) in Eppendorf tube was dissolved in 20ul of methanol and followed by adding a solution of carrier-free ... [124I]-NaI in 0.1N NaOH - recovery yield > 80% |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 34475100. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: I-124 is a positron emitter used only for PET imaging. Linked articles: PMID 34475100.