Tracer library / [131I]I-Tyr-d-peptide-PEG11-Tz
[131I]I-Tyr-d-peptide-PEG11-Tz
Also written as [I-131]I-Tyr-d-peptide-PEG11-Tz
- Radionuclide
- I-131 t½ 11549 min
- Modality
- Therapy
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- Tetrazine-bearing peptide probe (Tyr-d-peptide-PEG11-Tz) for pretargeted radioimmunotherapy
- Target / mechanism
- Click-to-chelate pretargeting via IEDDA reaction between tetrazine probe and TCO-Pertuzumab bound to HER2 PMID 42592442
- Clinical application
- Pretargeted radionuclide therapy for HER2-positive tumors using tetrazine probe following TCO-Pertuzumab pretargeting PMID 42592442
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | HPLC | >95% | ~99% | Tyr-d-peptide-PEG11-Tz | 42592442 2026 Acta Pharm Sin B For radiolabelling, 60 μg of Tyr-d-peptide-PEG11-Tz in 0.01 mol/L PBS and 105-120 MBq Na131I solution were added to an iodogen tube. The reaction occurred at 20 °C for 15 min - The radiochemical yield of [131I]I-Tyr-d-peptide-PEG11-Tz was greater than 95% |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 42592442. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 42592442: '60 μg of Tyr-d-peptide-PEG11-Tz in 0.01 mol/L PBS'.