Tracer library / [68Ga]Ga-DOTA-exendin-4

[68Ga]Ga-DOTA-exendin-4

Also written as [68Ga]Ga-DOTA-exendin-4; [Ga-68]Ga-DOTA-exendin-4
Radionuclide
Ga-68 t½ 67.71 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
1
Pancreatic beta-cell imagingCongenital hyperinsulinism

What it is

Compound class
GLP-1 receptor analog (Exendin-4 peptide) labeled with DOTA chelator
Target / mechanism
GLP-1 receptor (GLP-1R) PMID 40447542
Clinical application
Preoperative localization of insulinomas and imaging of endogenous hyperinsulinism/nesidioblastosis (pancreatic beta-cell disorders) PMID 37371836
Theranostic pair
[177Lu]Lu-DOTA-exendin-4

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Modular-Lab PharmTracer
Eckert & Ziegler
———>93 %—37634398
2023 Nucl Med Biol
cassette based synthesis module (Modular-Lab PharmTracer, Eckert & Ziegler) using commercially available cassettes

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. Trends in Presentation and Management of Endogenous Hyperinsulinaemic Hypoglycaemia Over the Last Three Decades at a Tertiary Care Centre (1992-2022).
    2024 · Indian J Endocrinol Metab · Clinical study
  2. An Uncommon Cause of Recurrent Presyncope, Dizziness, and Tachycardia: A Case Report of Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS).
    2023 · Biomedicines · Case report

Need this precursor?We can point you to suppliers for [68Ga]Ga-DOTA-exendin-4, or handle the enquiry for you.

Get in touch

Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impuritiesGe-68 breakthrough
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DOTA-exendin-4.

Get in touch

Notes

Added from reverse module search (stage 6); 1 article(s) with Ga-68.
Ask a question