Tracers / [68Ga]Ga-DOTA-r-a-ABA-CPCR4

[68Ga]Ga-DOTA-r-a-ABA-CPCR4

Also written as [68Ga]DOTA-r-a-ABA-CPCR4; [Ga-68]DOTA-r-a-ABA-CPCR4

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: preclinical study
Syntheses indexed: 2

Preclinical only, no clinical indication yet

What it is

Compound class: DOTA-conjugated cyclic pentapeptide CXCR4 ligand (CPCR4-based)
Target / mechanism: CXCR4 receptor ligand PMID 32724470
Clinical application: PET imaging of CXCR4 expression in cancer and inflammation (human B cell lymphoma xenograft model) PMID 32724470
Theranostic pair: <a href="/tracers/lu177-dotaraabacpcr4/">lu177-dotaraabacpcr4</a>

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	—	—	—	—	32724470 2020 Theranostics
Manual synthesis	—	—	—	—	DOTA-r-a-ABA-CPCR4	32724470 2020 Theranostics All peptides and their respective natGa-, natLu-, natY- and natBi- complexes were synthesized in analogy to previously published protocols

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impuritiesGe-68 breakthrough

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Ga-68. Also seen with Lu-177[1] (too few articles for own row). Compound class inferred from precursor name (not stated outright) -- PMID 32724470: 'DOTA-r-a-ABA-CPCR4 (entry 13)'. Stage set/updated at stage 23 from PMID 32724470: 'will be further evaluated in preclinical and clinical CXCR4-targeted dosimetry and RLT studies.'.