Tracer library / [68Ga]Ga-TRAP-(RGD)3

[68Ga]Ga-TRAP-(RGD)3

Also written as Ga-68 TRAP-(RGD)3; Ga-68-TRAP-(RGD)3; TRAP-(RGD)3

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 3

Preclinical only, no clinical indication yet Angiogenesis

What it is

Compound class: TRAP(RGD)3 - triazacyclononane-phosphinate (TRAP) chelator-conjugated cyclic RGD peptide (integrin-targeting peptide)
Target / mechanism: αvβ3-integrin binding via RGD peptide motif PMID 27992512
Clinical application: Imaging of αvβ3 integrin expression as a biomarker of anti-angiogenic therapy effects in experimental breast cancer PMID 27992512
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	SPE	66 ± 6% decay-corrected	—	TRAP(RGD)3	22682112 2012 EJNMMI Res
—	—	SPE	—	>98%	AVEBETRIN Scintomics, Fürstenfeldbruck, Germany	27992512 2016 PLoS One
Scintomics GRP / GRP-3V Scintomics	—	—	—	—	—	24120219 2014 Nucl Med Biol using a SCINTOMICS GRP module and an iThemba Labs generator

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Scintomics, Fürstenfeldbruck
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impuritiesGe-68 breakthrough

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 22682112: 'TRAP(RGD)3 was prepared as described before [6].'.