Tracers / [68Ga]Ga-TRAP-(RGD)3
[68Ga]Ga-TRAP-(RGD)3
Also written as Ga-68 TRAP-(RGD)3; Ga-68-TRAP-(RGD)3; TRAP-(RGD)3
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- TRAP(RGD)3 - triazacyclononane-phosphinate (TRAP) chelator-conjugated cyclic RGD peptide (integrin-targeting peptide)
- Target / mechanism
- αvβ3-integrin binding via RGD peptide motif PMID 27992512
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | SPE | 66 ± 6% yes | — | TRAP(RGD)3 | 22682112 2012 EJNMMI Res |
| — | — | SPE | — | >98% | AVEBETRIN Scintomics, Fürstenfeldbruck, Germany | 27992512 2016 PLoS One |
| — | — | — | — | — | — | 24120219 2014 Nucl Med Biol using a SCINTOMICS GRP module and an iThemba Labs generator |
| — | — | — | — | — | TRAP(RGD)3 | 22995902 2013 Nucl Med Biol |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-TRAP-(RGD)3.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 22682112: 'TRAP(RGD)3 was prepared as described before [6].'.