Tracer library / [11C]PK68

Structure of PK68 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 134203923

[11C]PK68

Also written as [11C]PK68; [C-11]PK68

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Preclinical only, no clinical indication yet

What it is

Compound class: carbamate-based RIPK1 inhibitor (PK68)
Target / mechanism: Receptor-interacting protein 1 kinase (RIPK1) PMID 35290562
Clinical application: —
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
In-house / custom built in-house	custom manifold	HPLC	9.1 ± 5.9% decay-corrected	>99%	Cyclohexyl-5-(2-aminobenzo[d]thiazol-6-yl)-2…Cyclohexyl-5-(2-aminobenzo[d]thiazol-6-yl)-2-methylpyridin-3-ylcarbamate (14)	35290562 2022 EJNMMI Radiopharm Chem An automated multi-purpose synthesizer developed in-house (Fukumura et al. 2007) was used for all radiosynthetic runs in the present study. - we obtained [11C]PK68 of 1200–1790 MBq with a radiochemical yield of 9.1 ± 5.9% (n = 10, decay-corrected to the end of irradiation)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with C-11. Stage set/updated at stage 39 from PMID 35290562: 'In a small-animal PET study, [11C]PK68 was rapidly distributed in the liver and kidneys of healthy mice after injection'.