Tracers / [11C]PK68
[11C]PK68
Also written as [11C]PK68; [C-11]PK68
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- carbamate-based RIPK1 inhibitor (PK68)
- Target / mechanism
- Receptor-interacting protein 1 kinase (RIPK1) PMID 35290562
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| In-house / custom built in-house | custom manifold | HPLC | 9.1 ± 5.9% yes | >99% | Cyclohexyl-5-(2-aminobenzo[d]thiazol-6-yl)-2-methylpyridin-3-ylcarbamate (14) | 35290562 2022 EJNMMI Radiopharm Chem An automated multi-purpose synthesizer developed in-house (Fukumura et al. 2007) was used for all radiosynthetic runs in the present study. — we obtained [11C]PK68 of 1200–1790 MBq with a radiochemical yield of 9.1 ± 5.9% (n = 10, decay-corrected to the end of irradiation) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with C-11.