Tracer library / [68Ga]NOTA-MI-exendin-4

[68Ga]NOTA-MI-exendin-4

Also written as [Ga-68]Ga-NOTA-MI-exendin-4

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Pancreatic beta-cell imaging Dosimetry and biodistribution studies Preclinical only, no clinical indication yet

What it is

Compound class: Exendin-4 peptide analogue conjugated to NOTA chelator via Met-Ile linker
Target / mechanism: GLP-1 receptor (GLP-1R) targeting PMID 37265006
Clinical application: Detection/localization of insulinomas PMID 37265006
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	—	>98%	NOTA-MI-exendin-4 piCHEM, Raaba-Grambach, Austria	37265006 2023 Mol Pharm labeled with 68Ga by adding 2.5 M HEPES

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: piCHEM
Typical final purification: —

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 37265006. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 37265006: 'Lys40[Mep((S-)NOTA-Met-Ile-Mal-)]exendin-4 (referred to as NOTA-MI-exendin-4)'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Ga-68 is a positron emitter used only for PET imaging. Linked articles: PMID 37265006, 40259061. Stage set/updated at stage 39 from PMID 37265006: 'We examined the renal retention and insulinoma targeting properties of these new exendin analogues in a nude mouse model bearing subcutaneous GLP-1R-expressing insulinomas.'.