Tracers / [18F]TTCO-IL2

[18F]TTCO-IL2

Also written as [18F]TTCO-IL2; [F-18]TTCO-IL2; trans-cyclooctene labelled interleukin-2
Radionuclide
F-18 t½ 109.7 min
Modality
PET
Production route
Cyclotron liquid target
Stage
Research
Syntheses indexed
1
Immune cell and immunotherapy imagingPreclinical only, no clinical indication yet

What it is

Compound class
—
Target / mechanism
Interleukin-2 receptor (subunits CD25/CD122/CD132) on activated T-cells; TCO-modified interleukin-2 (IL2) radioconjugate PMID 34123410 / DOI 10.1039/d1re00117e
Clinical application
(preclinical method paper) proposed for PET imaging of IL-2-receptor-expressing activated T-cells; in vitro uptake tracked CD25/CD122/CD132 expression PMID 34123410 / DOI 10.1039/d1re00117e
Theranostic pair
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Regulatory status

FDA
No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=interleukin-2+F-18
EMA (centralised)
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Other approvals
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Brand names
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Clinical use

Typical injected activity
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Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
FASTlab
GE HealthCare
vendor cassetteHPLC+SPE19.8 ± 2.6%
yes
>98%TCO-PEG4-IL234123410
2021 React Chem Eng
GE FASTlab™ automated synthesis module (GE Healthcare Life Sciences, Amersham, UK) — The automated synthesis produced [18F]TTCO-IL2 in 19.8 ± 2.6% RCY (d.c.) (n = 14) within 110 min from the start of synthesis in >98% RCP.

Precursor

Common precursor
trans-cyclooctene (TCO)-modified interleukin-2; radiolabelled by inverse-electron-demand Diels-Alder click with an 18F-tetrazine synthon PMID 34123410 / DOI 10.1039/d1re00117e
Suppliers seen in the literature
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Typical final purification
HPLC

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Target and application not filled - to be taken from the publication.