Tracers / [89Zr]DFO-11E10C11
[89Zr]DFO-11E10C11
Also written as [Zr-89]Zr-DFO-11E10C11
- Radionuclide
- Zr-89 t½ 4704 min
- Modality
- Therapy
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- DFO-conjugated anti-CDH3 monoclonal antibody
- Target / mechanism
- CDH3 (P-cadherin) targeting via anti-CDH3 monoclonal antibody 11E10C11 PMID 41570246
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | >99% | >99% | DFO-11E10C11 | 41570246 2026 Mol Pharm A solution of 89Zr(IV) oxalate ... was adjusted to pH 7.0 using 0.5 M Na2CO3 ... CDH3-DFO conjugate was then added at a 1:2 molar ratio ... incubated at 37 °C in a metal bath for 90 min — TLC analysis demonstrated labeling yields >99% for both radiolabeled conjugates |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41570246. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41570246: 'Synthesis of DFO-11E10C11'.