Tracers / [177Lu]Lu-cAC10
[177Lu]Lu-cAC10
Also written as [Lu-177]Lu-cAC10
- Radionuclide
- Lu-177 t½ 9584.6 min
- Modality
- Therapy
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- Anti-CD30 monoclonal antibody conjugated with DOTA (radioimmunoconjugate)
- Target / mechanism
- CD30 receptor, overexpressed in lymphomas PMID 40456588
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | — | >90% | cAC10 antibody conjugated with p-SCN-Bn-DOTA Macrocyclics | 40456588 2025 J Nucl Med Conjugation of the antibody to DOTA was performed by incubation with p-SCN-Bn-DOTA (Macrocyclics). |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 40456588. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 40456588: 'cAC10 antibody (IgG1 κ) was produced by Proteogenix. Conjugation of the antibody to DOTA was performed by incubation with p-SCN-Bn-DOTA (Macrocyclics).'.