Tracer library / [68Ga]TacBOMB2

[68Ga]TacBOMB2

Also written as [Ga-68]Ga-TacBOMB2

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: Reported once
Syntheses indexed: 1

Preclinical only, no clinical indication yet Receptor expression phenotyping

What it is

Compound class: DOTA-conjugated bombesin(7-14) analog ([Thz14]Bombesin(7-14) peptide)
Target / mechanism: GRPR agonist PMID 36838968
Clinical application: PET imaging of GRPR-expressing tumors (e.g., prostate cancer, PC-3 xenografts) PMID 36838968
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	HPLC+SPE	51-80% decay-corrected	>95%	DOTA-conjugated TacBOMB2	36838968 2023 Molecules Purified 68GaCl3 in 0.5 mL of water was added to a 4 mL glass vial preloaded with 0.7 mL of HEPES buffer (2 M, pH 5.0) and 10 μL of precursor solution (1 mM). The radiolabeling reaction was carried out under microwave heating for 1 min before being purified by HPLC using the semi-preparative column. - 68Ga-labeled TacBOMB2, TacBOMB3, and AMBA were obtained in 51–80% decay-corrected radiochemical yields

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 36838968. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 36838968: 'DOTA-conjugated TacBOMB2, TacBOMB3, and TacBOMB4 were obtained in 30–55% yields'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Ga-68 is a positron emitter used only for PET imaging. Linked articles: PMID 36838968.