Tracer library / [225Ac]Ac-DOTA-PKU525

[225Ac]Ac-DOTA-PKU525

Also written as [Ac-225]Ac-DOTA-PKU525

Radionuclide: Ac-225 t½ 14284.8 min
Modality: Therapy
Production route: —
Stage: Reported once
Syntheses indexed: 1

Preclinical only, no clinical indication yet Fibroblast activation / tumour stroma

What it is

Compound class: FAP-targeting antibody (DOTA-conjugated)
Target / mechanism: Fibroblast activation protein (FAP) PMID 39474138
Clinical application: Targeted alpha therapy for FAP-expressing tumors (preclinical) PMID 39474138
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	80	—	p-SCN-Bn-DOTA Macrocyclics	39474138 2023 Chem Biomed Imaging The procedure of 225Ac radiolabeling was explored with the one-step labeling method illustrated in Figure 1A. - an RCY of 80% was achieved when the molar amount of PKU-DOTA with DAR 7.72 was 3.2 nmol, PKU-DOTA with DAR 3.87 was 6.4 nmol, and PKU-DOTA with DAR1.85 was 12.8 nmol

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Macrocyclics
Typical final purification: —

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 39474138. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty.