Tracer library / [111In]AT2S

[111In]AT2S

Also written as [In-111]In-AT2S

Radionuclide: In-111 t½ 4031.6 min
Modality: Therapy
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Preclinical only, no clinical indication yet

What it is

Compound class: DOTA-conjugated somatostatin-14 (SST-14) analog radioligand
Target / mechanism: Binds with high affinity to all five somatostatin receptor subtypes (SST1-5R) PMID 38543286
Clinical application: Neuroendocrine tumors (NETs) PMID 38543286
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	none	>95%	>95%	AT2S In-house / non-commercial (various)	38543286 2024 Pharmaceutics The radiolabeling with [111In]InCl3 was conducted in low protein binding Eppendorf tubes. - The radiopeptides were obtained in >95% radiochemical yields

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: In-house / non-commercial (various)
Typical final purification: —

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 38543286. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Stage set/updated at stage 39 from PMID 38543286: 'A pilot SPECT/CT imaging study conducted in mice bearing hSST2R-positive xenografts failed to visualize the xenografts'.