Tracer library / [177Lu]Lu-pepa-pic2-C-Hex-KuE

[177Lu]Lu-pepa-pic2-C-Hex-KuE

Also written as [Lu-177]Lu-pepa-pic2-C-Hex-KuE

Radionuclide: Lu-177 t½ 9584.6 min
Modality: Therapy
Production route: —
Stage: Reported once
Syntheses indexed: 1

Prostate cancer Preclinical only, no clinical indication yet

What it is

Compound class: PSMA-targeting urea-based (C-Hex-KuE) small molecule with pepa-pic2 trifunctional chelator
Target / mechanism: Prostate-specific membrane antigen (PSMA) PMID 41324598
Clinical application: Prostate cancer theranostics PMID 41324598
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	—	—	—	pepa-pic2-C-Hex-KuE	41324598 2025 J Am Chem Soc The formation of [177Lu]Lu-pepa-pic2-C-Hex-KuE and [161Tb]Tb-pepa-pic2-C-Hex-KuE was achieved under identical reaction conditions as previously employed for the 86Y analogue (80 °C, pH 5.5)

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41324598. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41324598: 'pepa-pic2-C-Hex-KuE'.