Tracer library / [68Ga]Ga-DOTANOC
[68Ga]Ga-DOTANOC
Also written as [68Ga]Ga-DOTANOC; [Ga-68]Ga-DOTANOC; DOTA-NOC; DOTANOC; Ga-68 DOTA-NOC; Ga-68 DOTANOC; Ga-68-DOTANOC
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 6
What it is
- Compound class
- Radiolabelled somatostatin analogue peptide (1-Nal3-octreotide, DOTA-conjugated)
- Target / mechanism
- Somatostatin receptors, primarily subtypes 2 and 5 (broader subtype profile than DOTATOC) PMID 17874094
- Clinical application
- Neuroendocrine tumour PET imaging PMID 17874094
- Theranostic pair
- [47Sc]Sc-DOTANOC
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| FASTlab GE HealthCare | — | SPE | 66.13±3.35 decay-corrected | 99.38±0.31 | DOTANOC ABX | 25369268 2014 PLoS One Most of the synthesis was performed using an automated process programmed in a FastLab module (General Electric Healthcare). - the decay-corrected radiochemical yield (%) was 54.03±2.45, 66.13±3.35 and 67.81±3.12 |
| ITG labeling module ITG (Isotope Technologies Garching) | vendor cassette | SPE | — | 0.21 ± 0.18 Mean impurity B (%) ± SD | DOTA-NOC acetate ABX | 25932354 2015 EJNMMI Res a labelling module for manual operation and a GMP grade 925 MBq 68Ge/68Ga generator were obtained from ITG (Gärching/Munich, Germany) |
| FASTlab GE HealthCare | — | SPE | 66.13 decay-corrected | 99.38 | DOTANOC ABX | 25369268 2014 PLoS One Most of the synthesis was performed using an automated process programmed in a FastLab module (General Electric Healthcare). - 66.1% for 68Ga-DOTANOC |
| TRACERlab FX FN GE HealthCare | — | — | 68% ± 3% | >97% | DOTANOC | 30672007 2019 J Labelled Comp Radiopharm Automated production of [68 Ga]Ga-DOTANOC and [68 Ga]Ga-PSMA-11 using a TRACERlab FXFN synthesis module. - 68% ± 3% for [68 Ga]Ga-DOTANOC (n > 100) |
| Manual synthesis n/a | — | — | — | >95% | — | 27907840 2017 Nucl Med Biol without use of any synthesis module |
| Scintomics GRP / GRP-3V Scintomics | — | — | — | — | — | 24120219 2014 Nucl Med Biol using a SCINTOMICS GRP module and an iThemba Labs generator |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- Triple-tracer PET (18F-FDG, 68Ga-DOTANOC, 68Ga-FAPI) maps inter- and intra-lesional heterogeneity in metastatic high-grade neuroendocrine neoplasms.2026 · Sci Rep · Prospective
- PET/MRI versus PET/CT in oncology: a prospective single-center study of 330 examinations focusing on implications for patient management and cost considerations.2020 · Eur J Nucl Med Mol Imaging · Prospective
- Prospective evaluation of 68Ga-DOTANOC positron emission tomography/computed tomography and 131I-meta-iodobenzylguanidine single-photon emission computed tomography/computed tomography in extra-adrenal paragangliomas, including uncommon primary sites and to define their diagnostic roles in current scenario.2019 · Nucl Med Commun · Prospective
- (68)Ga-DOTA-peptide: A novel molecular biomarker for nasopharyngeal carcinoma.2016 · Head Neck · Prospective
- Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT within patients with gastroenteropancreatic neuroendocrine tumors.2013 · J Nucl Med · Prospective
- A Rare Case of Neuroendocrine Prostate Cancer Detected on 68Ga - DOTANOC Positron Emission Tomography/Computed Tomography (PET/CT).2024 · Cureus · Clinical study
- Sex-differences in [68Ga]Ga-DOTANOC biodistribution.2019 · Nucl Med Biol · Clinical study
- Pitfall in follow-up imaging of pancreatic neuroendocrine tumor by somatostatin receptor PET.2013 · Neuro Endocrinol Lett · Clinical study
- Seeing Beyond 68GA-DOTANOC and 18F-FDG PET/CT: 68GA-FAPI Only Uptake in a Rare Metastatic Well-differentiated Grade I Pancreatic Neuroendocrine Tumor.2026 · Clin Nucl Med · Case report
- Prolactin Secreting Pituitary Carcinoma and the Role of Peptide Receptor Radionuclide Therapy: A Brief Report.2024 · Neurol India · Case report
Show all 11 clinical studies
Precursor
Need this precursor?We can point you to suppliers for [68Ga]Ga-DOTANOC, or handle the enquiry for you.
Get in touchQuality control Derived from the published synthesis
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator-produced per synthesis data (PMID 25369268) -> Ge-68 breakthrough; receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DOTANOC.
Get in touchNotes
Added from reverse module search (stage 6); 11 article(s) with Ga-68. Also seen with Cu-61[1] (too few articles for own row).