Tracers / [68Ga]Ga-DOTANOC
[68Ga]Ga-DOTANOC
Also written as [68Ga]Ga-DOTANOC; [Ga-68]Ga-DOTANOC; DOTA-NOC; DOTANOC; Ga-68 DOTA-NOC; Ga-68 DOTANOC; Ga-68-DOTANOC
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 12
What it is
- Compound class
- Radiolabelled somatostatin analogue peptide (1-Nal3-octreotide, DOTA-conjugated)
- Target / mechanism
- Somatostatin receptors, primarily subtypes 2 and 5 (broader subtype profile than DOTATOC) PMID 17874094
- Clinical application
- Neuroendocrine tumour PET imaging PMID 17874094
- Theranostic pair
- <a href="/tracers/sc47-dotanoc/">sc47-dotanoc</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| FASTlab GE HealthCare | — | SPE | 66.13±3.35 yes | 99.38±0.31 | DOTANOC ABX | 25369268 2014 PLoS One Most of the synthesis was performed using an automated process programmed in a FastLab module (General Electric Healthcare). — the decay-corrected radiochemical yield (%) was 54.03±2.45, 66.13±3.35 and 67.81±3.12 |
| ITG labeling module ITG (Isotope Technologies Garching) | vendor cassette | SPE | — | Mean impurity B (%) ± SD 0.21 ± 0.18 | DOTA-NOC acetate ABX | 25932354 2015 EJNMMI Res a labelling module for manual operation and a GMP grade 925 MBq 68Ge/68Ga generator were obtained from ITG (Gärching/Munich, Germany) |
| — | — | — | — | — | — | 42115250 2026 Sci Rep |
| — | — | — | — | — | — | 41693498 2026 Nucl Med Commun |
| — | — | — | — | — | — | 38361734 2024 Cureus |
| FASTlab GE HealthCare | — | SPE | 66.13 yes | 99.38 | DOTANOC ABX | 25369268 2014 PLoS One Most of the synthesis was performed using an automated process programmed in a FastLab module (General Electric Healthcare). — 66.1% for 68Ga-DOTANOC |
| — | — | — | — | — | — | 23522791 2013 Appl Radiat Isot |
| — | — | — | 68% ± 3% | exceeding 97% | DOTANOC | 30672007 2019 J Labelled Comp Radiopharm Automated production of [68 Ga]Ga-DOTANOC and [68 Ga]Ga-PSMA-11 using a TRACERlab FXFN synthesis module. — 68% ± 3% for [68 Ga]Ga-DOTANOC (n > 100) |
| — | — | — | — | >95% | — | 27907840 2017 Nucl Med Biol without use of any synthesis module |
| — | — | — | — | — | DOTANOC | 23297077 2013 J Nucl Med Labeling of DOTANOC and DOTATATE with (68)Ga was standardized using a fully automated synthesis device. |
| — | — | — | — | — | — | 24120219 2014 Nucl Med Biol using a SCINTOMICS GRP module and an iThemba Labs generator |
| — | — | — | — | — | — | 42410759 2026 Clin Nucl Med |
Precursor
- Common precursor
- DOTANOC PMID 25369268 (DOI 10.1371/journal.pone.0111624)
- Suppliers seen in the literature
- ABX GmbH (Radeberg, Germany)
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- SPE
Need this precursor?We can point you to suppliers for [68Ga]Ga-DOTANOC, or handle the enquiry for you.
Get in touchQuality control Derived from the published synthesis
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator-produced per synthesis data (PMID 25369268) -> Ge-68 breakthrough; receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DOTANOC.
Get in touchNotes
Added from reverse module search (stage 6); 11 article(s) with Ga-68. Also seen with Cu-61[1] (too few articles for own row).