Tracer library / [47Sc]Sc-DOTANOC

Structure of DOTANOC (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 15518147

[47Sc]Sc-DOTANOC

Also written as DOTANOC; Sc-47-DOTANOC

Radionuclide: Sc-47 t½ 4823.8 min
Modality: Therapy
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Preclinical only, no clinical indication yet

What it is

Compound class: DOTA-conjugated somatostatin analogue (DOTANOC)
Target / mechanism: —
Clinical application: —
Theranostic pair: [68Ga]Ga-DOTANOC

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	custom manifold	—	94.8 ± 2.1%	99.6 ± 0.7%	DOTANOC ABX	29503846 2017 EJNMMI Radiopharm Chem A system of syringes, peristaltic pumps and three-way valves (see schematic of the panel in Fig. 2) was used to transfer the reagents from outside into the hot cell. - Using Method A, the solution was concentrated on the SCX cation exchange resin (used as the second column) and eluted with 700 μL 4.8 M NaCl/0.1 M HCl solution (pH 0–0.5), collecting 94.8 ± 2.1% of the total 47Sc activity.

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: ABX
Typical final purification: —

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 1 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Diagnostic pair signal at discovery: YES - Ga-68. Stage set/updated at stage 39 from PMID 29503846: 'Finally, preclinical SPECT/CT experiments were performed in tumor-bearing mice and compared with the PET image of the 44Sc labeled counterpart.'.