Neuroendocrine neoplasms

By indication / Neuroendocrine neoplasms

15 imaging agents and 35 therapeutic agents reported for this indication. Stage reflects how far each has been taken, not what is available in any given country.

Imaging

Agent	Isotope	Stage	Syntheses
[68Ga]Ga-DOTATATE paired with [177Lu]Lu-DOTATATE	Ga-68	Approved	94
[68Ga]Ga-DOTA-TOC paired with [177Lu]Lu-DOTA-TOC	Ga-68	Approved	86
[18F]FDOPA	F-18	Approved	49
[123I]MIBG paired with [131I]MIBG	I-123	—	33
[18F]SiTATE	F-18	—	14
[68Ga]Ga-DOTANOC paired with [47Sc]Sc-DOTANOC	Ga-68	—	12
[64Cu]Cu-DOTATATE paired with [177Lu]Lu-DOTATATE	Cu-64	Approved	6
[18F]FETrp	F-18	Research	5
[64Cu]Cu-sartate paired with [67Cu]Cu-SARTATE	Cu-64	first-in-human	4
[18F]AmBF3-TATE	F-18	preclinical study	4
[18F]FET-bAG-TOCA paired with [177Lu]Lu-DOTATATE	F-18	Research	3
[18F]AlF-NOTA-octreotide	F-18	—	3
[68Ga]Ga-DOTA-D-Phe-Tyr3-octreotide	Ga-68	approved/clinical use	3
[18F]FB(ePEG12)12-exendin-4	F-18	Phase 1 clinical study (first-in-human)	2
[68Ga]Ga-DOTA-CP04	Ga-68	—	2

Therapy

Agent	Isotope	Stage	Syntheses
[177Lu]Lu-DOTATATE paired with [68Ga]Ga-DOTATATE	Lu-177	approved (FDA-approved)	77
[177Lu]Lu-DOTA-TOC paired with [68Ga]Ga-DOTA-TOC	Lu-177	—	28
[90Y]Y-DOTA-TOC paired with [68Ga]Ga-DOTA-TOC	Y-90	—	19
[131I]MIBG paired with [123I]MIBG	I-131	approved	19
[90Y]Y-microsphere	Y-90	approved	11
[225Ac]Ac-DOTATATE paired with [68Ga]Ga-DOTATATE	Ac-225	Phase 1b/3 clinical trial	8
[177Lu]Lu-DOTA-LM3	Lu-177	first-in-human	8
[211At]At-MABG	At-211	preclinical	7
[90Y]Y-DOTA-Phe1-Tyr3-octreotide	Y-90	Phase I/II	7
[212Pb]Pb-PSC-PEG2-TOC	Pb-212	—	6
[177Lu]Lu-DOTA-JR11	Lu-177	—	6
[177Lu]Lu-oxodotreotide	Lu-177	—	5
[177Lu]Lu-CP04	Lu-177	—	4
[90Y]Y-DOTATATE paired with [68Ga]Ga-DOTATATE	Y-90	—	4
[161Tb]Tb-DOTATATE paired with [68Ga]Ga-DOTATATE	Tb-161	—	4
[177Lu]Lu-HA-DOTATATE	Lu-177	—	4
[161Tb]Tb-DOTA-LM3	Tb-161	Phase 0 clinical study	3
[166Ho]Ho-166-PLLA	Ho-166	—	3
[212Pb]Pb-DOTAMTATE	Pb-212	preclinical	3
[90Y]Y-DOTA-DPhe1-Tyr3-octreotide	Y-90	—	2
[161Tb]Tb-3p-C-NETA paired with [68Ga]Ga-3p-C-NETA	Tb-161	—	1
[161Tb]Tb-DOTA-TOC paired with [68Ga]Ga-DOTA-TOC	Tb-161	preclinical study	1
[225Ac]Ac-DOTA-LM3	Ac-225	first-in-human	1
[177Lu]Lu-EB-TATE	Lu-177	—	1
[90Y]Y-90-DOTATOC/DOTATATE	Y-90	—	1
[177Lu]Lu-LNC1010	Lu-177	first-in-human	1
[177Lu]Lu-DOTA-EB-TATE	Lu-177	—	1
[177Lu]Lu-DOTA-GA4	Lu-177	preclinical study	1
[177Lu]Lu-DOTA-GA13	Lu-177	Reported once	1
[68Ga]TATE-46	Ga-68	preclinical study	1
[203Pb]eSOMA-01	Pb-203	Reported once	1
[203Pb]eSOMA-02	Pb-203	Reported once	1
[212Pb]Pb-eSOMA-02	Pb-212	Reported once	1
[68Ga]C803-GIP	Ga-68	Reported once	1
[225Ac]Ac-crown-TATE	Ac-225	—

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