Tracers / [18F]FB(ePEG12)12-exendin-4
[18F]FB(ePEG12)12-exendin-4
Also written as [18F]FB(ePEG12)12-exendin-4; [F-18]FB(ePEG12)12-exendin-4
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Phase 1 clinical study (first-in-human)
- Syntheses indexed
- 2
What it is
- Compound class
- exendin-4-based GLP-1 receptor agonist peptide probe
- Target / mechanism
- GLP-1 receptor (GLP-1R) PMID 34294854
- Clinical application
- PET imaging of insulinoma and pancreatic beta-cell mass via GLP-1 receptor targeting PMID 34294854
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | HPLC+SPE | — | — | pre(ePEG12)12-exendin-4 KNC Laboratories Co. Ltd., Kobe, Japan | 34294854 2021 Sci Rep |
| In-house / custom built | custom manifold | HPLC | — | — | pre(ePEG12)12-Ex4 KNC Laboratories Co. Ltd., Kobe, Japan | 34489868 2021 Front Endocrinol (Lausanne) We synthesized 18F-Ex4 probe using an in-house automated synthesis equipment. |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FB(ePEG12)12-exendin-4.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 34294854: 'pre(ePEG12)12-exendin-4 (KNC Laboratories Co. Ltd., Kobe, Japan)'. Stage set/updated at stage 23 from PMID 34489868: 'First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas.'.