Tracer library / [18F]FB(ePEG12)12-exendin-4

[18F]FB(ePEG12)12-exendin-4

Also written as [18F]FB(ePEG12)12-exendin-4; [F-18]FB(ePEG12)12-exendin-4

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 1

Pancreatic beta-cell imaging Neuroendocrine neoplasms

What it is

Compound class: exendin-4-based GLP-1 receptor agonist peptide probe
Target / mechanism: GLP-1 receptor (GLP-1R) PMID 34294854
Clinical application: PET imaging of insulinoma and pancreatic beta-cell mass via GLP-1 receptor targeting PMID 34294854
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	HPLC+SPE	—	—	pre(ePEG12)12-exendin-4 KNC Laboratories Co. Ltd., Kobe, Japan	34294854 2021 Sci Rep

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

[18F]FB(ePEG12)12-exendin-4 noninvasive imaging of insulinoma negative for insulin immunostaining on specimen from endoscopic ultrasonography-guided fine needle aspiration: a case report with review of literature.
2024 · Endocr J · Case report

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: KNC Laboratories Co. Ltd., Kobe
Typical final purification: —

Need this precursor?We can point you to suppliers for [18F]FB(ePEG12)12-exendin-4, or handle the enquiry for you.

Get in touch

Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [18F]FB(ePEG12)12-exendin-4.

Get in touch

Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 34294854: 'pre(ePEG12)12-exendin-4 (KNC Laboratories Co. Ltd., Kobe, Japan)'. Stage set/updated at stage 23 from PMID 34489868: 'First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas.'. | Stage 30 (2026-09-18): Stage was 'Phase 1 clinical study (first-in-human)'; normalised to 'Clinical research', original wording kept here.