Tracer library / [18F]SiTATE

[18F]SiTATE

Also written as [18F]SiTATE; [F-18]SiTATE

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 6

Neuroendocrine neoplasms

What it is

Compound class: Radiolabelled somatostatin analogue peptide (silicon-fluoride-acceptor SiFA-TATE conjugate)
Target / mechanism: Somatostatin receptor subtype 2 (SSTR2) PMID 40445313
Clinical application: Neuroendocrine tumour and phaeochromocytoma/paraganglioma PET imaging PMID 40445313
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Scintomics GRP 2V Scintomics	custom manifold	SPE	53 ± 10 not corrected	97 ± 0.9%	SiTATE precursor	37819534 2023 EJNMMI Radiopharm Chem The process was developed on a Scintomics GRP™ 2V automated synthesis unit (ASU) - average radiochemical yields of 53 ± 10% end-of-synthesis
Modular-Lab (model not stated) Eckert & Ziegler	—	SPE	32 ± 1 decay-corrected	—	SiTATE precursor	37819534 2023 EJNMMI Radiopharm Chem At University Medical Center Groningen, an Eckert and Ziegler modular lab system is used. - The average decay-corrected radiochemical yield is 32 ± 1% (n = 3).
TRACERlab MX GE HealthCare	vendor cassette	SPE	—	—	— ABX	37819534 2023 EJNMMI Radiopharm Chem ABX has developed a process for the GE TRACERlab MX as well as for the ORA Neptis® RS/DB synthesizer.
Neptis Plug / Neptis RS ORA	vendor cassette	SPE	—	—	— ABX	37819534 2023 EJNMMI Radiopharm Chem as well as for the ORA Neptis® RS/DB synthesizer
AllinOne (AiO) Trasis	vendor cassette	SPE	40 ± 5 not corrected	≥ 95%	—	37819534 2023 EJNMMI Radiopharm Chem RQS (Ruffani Quality Solutions) provides a novel process to be implemented on the Trasis AllinOne ASU without the need of any HPLC equipment. - an overall yield of 40 ± 5% (n = 5) end-of-synthesis
Scintomics GRP / GRP-3V Scintomics	—	—	54 ± 4% not corrected	96.3 ± 0.1%	—	32828007 2020 Nucl Med Biol on the Scintomics GRP™ platform for clinical NET imaging - [18F]SiTATE was obtained in 54 ± 4% (n = 3) non-decay corrected radiochemical yield (RCY)

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

Estimation of split renal function on PET using the SSTR-targeting radioligands [18F]SiTATE, [68Ga]Ga-DOTA-TATE and [68Ga]Ga-DOTA-TOC in a theranostic setting.
2026 · Eur J Nucl Med Mol Imaging · Retrospective
[18F]SiTATE-PET/CT for detection of pheochromocytomas and paragangliomas: comparison of biochemical secretion, genotype and imaging metrics.
2025 · Eur J Nucl Med Mol Imaging · Retrospective
[18F]SiTATE PET for PRRT selection and monitoring metastatic tumors of the adrenal medulla and extra-adrenal paraganglia.
2026 · Eur J Nucl Med Mol Imaging · Clinical study
Validation of the standardization framework SSTR-RADS 1.0 for neuroendocrine tumors using the novel SSTR‑targeting peptide [18F]SiTATE.
2024 · Eur Radiol · Clinical study
Comparison of somatostatin receptor expression in patients with neuroendocrine tumours with and without somatostatin analogue treatment imaged with [18F]SiTATE.
2023 · Front Oncol · Clinical study
PET Imaging of Meningioma Using the Novel SSTR-Targeting Peptide 18F-SiTATE.
2021 · Clin Nucl Med · Case report

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: ABX
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 5 article(s) with F-18.