Tracers / [177Lu]Lu-DOTA-GA4
[177Lu]Lu-DOTA-GA4
Also written as [Lu-177]Lu-DOTA-GA4
- Radionuclide
- Lu-177 t½ 9584.6 min
- Modality
- Therapy
- Production route
- —
- Stage
- preclinical study
- Syntheses indexed
- 1
What it is
- Compound class
- DOTA-conjugated gastramide peptide (CCK2R-targeting)
- Target / mechanism
- Cholecystokinin-2 receptor (CCK2R) targeting PMID 41509636
- Clinical application
- Radiopharmaceutical therapy of neuroendocrine tumors (CCK2R-expressing) PMID 41509636
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | HPLC | — | ≥99% | DOTA-GA4 | 41509636 2026 RSC Adv These DOTA-peptides were subsequently radiolabeled with 177Lu as detailed in the SI materials. |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41509636. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41509636: 'DOTA-GA4, DOTA-GA13, and the clinical standard CP04 were synthesized and radiolabeled with lutetium-177 (177Lu)'. Stage set/updated at stage 23 from PMID 41509636: 'This study presents the evaluation of novel gastramide theranostic compounds GA4 and GA13, designed with enhanced structural properties for superior CCK2R targeting.'.