Tracer library / [68Ga]Ga-DOTA-CP04

[68Ga]Ga-DOTA-CP04

Also written as [68Ga]Ga-DOTA-CP04; [Ga-68]Ga-DOTA-CP04

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

Neuroendocrine neoplasms

What it is

Compound class: DOTA-conjugated cholecystokinin-2 receptor agonist peptide
Target / mechanism: Cholecystokinin-2 receptor agonist PMID 31659509
Clinical application: PET imaging of neuroendocrine tumors overexpressing the cholecystokinin-2 receptor PMID 31659509
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
iPHASE MultiSyn iPHASE Technologies	vendor cassette	SPE	74.8% ± 3.4% decay-corrected	92-94%	DOTA-CP04 prepared in-house	31659509 2019 EJNMMI Radiopharm Chem iPHASE MultiSyn radiosynthesizer, to produce 68Ga-labelled DOTA-CP04 - [68Ga]Ga-DOTA-CP04 was prepared reproducibly in 74.8% ± 3.4% (n = 10) decay-corrected yield
Manual synthesis n/a	—	HPLC	>90%	—	CP04	26315862 2015 Nucl Med Rev Cent East Eur Complex formation needed 5 min in microwave oven or 12 min in thermo-block at 95°C. - Yields of CP04 radiolabelling were greater than 90% for all three radionuclides.

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: prepared in-house
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impuritiesGe-68 breakthrough

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 31659509: 'DOTA-CP04 precursor (30 μg) in 0.5 M sodium acetate solution'.