Tracers / [68Ga]Ga-DOTA-CP04
[68Ga]Ga-DOTA-CP04
Also written as [68Ga]Ga-DOTA-CP04; [Ga-68]Ga-DOTA-CP04
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- DOTA-conjugated cholecystokinin-2 receptor agonist peptide
- Target / mechanism
- Cholecystokinin-2 receptor agonist PMID 31659509
- Clinical application
- PET imaging of neuroendocrine tumors overexpressing the cholecystokinin-2 receptor PMID 31659509
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| iPHASE MultiSyn iPHASE Technologies | vendor cassette | SPE | 74.8% ± 3.4% yes | 92-94% | DOTA-CP04 prepared in-house | 31659509 2019 EJNMMI Radiopharm Chem iPHASE MultiSyn radiosynthesizer, to produce 68Ga-labelled DOTA-CP04 — [68Ga]Ga-DOTA-CP04 was prepared reproducibly in 74.8% ± 3.4% (n = 10) decay-corrected yield |
| — | — | HPLC | >90% | — | CP04 | 26315862 2015 Nucl Med Rev Cent East Eur Complex formation needed 5 min in microwave oven or 12 min in thermo-block at 95°C. — Yields of CP04 radiolabelling were greater than 90% for all three radionuclides. |
Need this precursor?We can point you to suppliers for [68Ga]Ga-DOTA-CP04, or handle the enquiry for you.
Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DOTA-CP04.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 31659509: 'DOTA-CP04 precursor (30 μg) in 0.5 M sodium acetate solution'.