Tracers / [18F]AlF-NOTA-octreotide
[18F]AlF-NOTA-octreotide
Also written as [18F]AlF-NOTA-Octreotide; [F-18]AlF-NOTA-Octreotide
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- NOTA-conjugated somatostatin analog (octreotide) radiolabeled via Al18F
- Target / mechanism
- Binds somatostatin receptor subtype 2 (SSTR2) PMID 31997090
- Clinical application
- PET/CT imaging of somatostatin receptor expression in neuroendocrine neoplasms PMID 42014536
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| FASTlab 2 GE HealthCare | vendor cassette | SPE | 42 ± 1.5% | >95% | NOTA-octreotide (NOTA-D-phe-cyclo[Cys-Phe-D-Trp-Lys-Thr-Cys]-Throl) WuXi AppTec | 42014536 2026 EJNMMI Radiopharm Chem GE Fastlab 2 automated synthesis module (General Electric Healthcare) — a radiochemical yield (RCY) of 42 ± 1.5% |
| AllinOne (AiO) Trasis | vendor cassette | SPE | 26.1 ± 3.6% yes | 96.3 ± 0.2% | NOTA-octreotide trifluoracetate ABX | 31997090 2020 EJNMMI Radiopharm Chem [18F]AlF-NOTA-octreotide was synthesized in an AllInOne® synthesis module (Trasis, Ans, Belgium). — a radiochemical yield of 26.1 ± 3.6% (dc) |
| — | — | — | — | — | — | 41699279 2026 Eur J Nucl Med Mol Imaging |
Need this precursor?We can point you to suppliers for [18F]AlF-NOTA-octreotide, or handle the enquiry for you.
Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]AlF-NOTA-octreotide.
Get in touchNotes
Added from reverse module search (stage 6); 7 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 42014536: 'NOTA-octreotide (NOTA-D-phe-cyclo[Cys-Phe-D-Trp-Lys-Thr-Cys]-Throl)'.