Tracers / [68Ga]Ga-3p-C-NETA

[68Ga]Ga-3p-C-NETA

Also written as [68Ga]Ga-3p-C-NETA; [Ga-68]Ga-3p-C-NETA

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: preclinical study
Syntheses indexed: 1

Radiochemistry methodology

What it is

Compound class: chelator (3p-C-NETA), free chelator not conjugated to targeting vector
Target / mechanism: —
Clinical application: —
Theranostic pair: <a href="/tracers/tb161-3pcneta/">tb161-3pcneta</a>

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	97.7 ± 0.1%	—	3p-C-NETA	35966589 2022 Theranostics 3p-C-NETA was labeled by adding [68Ga]GaCl3: (5 MBq, 0.5 M NaOAc, pH 5.2)... to the 3p-C-NETA solution... and the reaction mixture (V= 1 mL) was incubated for 12 min at the desired temperature. — At 95 °C, an excellent RCC of 97.7 ± 0.1% was observed (Figure 3, Table S1).

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impuritiesGe-68 breakthrough

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 35966589: '3p-C-NETA was labeled by adding [68Ga]GaCl3'. Stage set/updated at stage 23 from PMID 35966589: 'Radiolabeled somatostatin analogues'.