Tracer library / [161Tb]Tb-3p-C-NETA

[161Tb]Tb-3p-C-NETA

Also written as [161Tb]Tb-3p-C-NETA; [Tb-161]Tb-3p-C-NETA

Radionuclide: Tb-161 t½ 9907.2 min
Modality: Therapy
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Neuroendocrine neoplasms Preclinical only, no clinical indication yet Peptide receptor radionuclide therapy

What it is

Compound class: Somatostatin analogue peptide conjugated to NETA-derived chelator (3p-C-NETA-TATE)
Target / mechanism: Somatostatin receptor targeting via TATE (octreotate) peptide PMID 35966589
Clinical application: —
Theranostic pair: [68Ga]Ga-3p-C-NETA

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	>95%	—	3p-C-NETA	35966589 2022 Theranostics 3p-C-NETA was labeled by adding... [161Tb]TbCl3: (4 MBq, 0.1M NaOAc, pH 4.1)... to the 3p-C-NETA solution... and the reaction mixture (V= 1 mL) was incubated for 12 min at the desired temperature. - a RCC of >95% was observed at 40 °C for 3p-C-NETA (10 µM)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityOsmolalityMolar activityMetal impurities

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with Tb-161. Stage set/updated at stage 39 from PMID 35966589: '3p-C-NETA is a versatile chelator that can be used for both diagnostic applications (Al18F) and targeted radionuclide therapy (213Bi, 177Lu, 161Tb).'.