Tracers / [18F]FET-bAG-TOCA

[18F]FET-bAG-TOCA

Also written as [18F]FET-bAG-TOCA; [F-18]FET-bAG-TOCA; FET-bAG-TOCA; fluoroethyl triazole [Tyr3]octreotate
Radionuclide
F-18 t½ 109.7 min
Modality
PET
Production route
Cyclotron liquid target
Stage
Research
Syntheses indexed
3
Neuroendocrine neoplasms

What it is

Compound class
Peptide (somatostatin analogue)
Target / mechanism
SSTR2 PMID 32252406 / DOI 10.1021/acs.jmedchem.9b02017
Clinical application
Neuroendocrine tumours PMID 27173162; PMID 38331457 / DOI 10.2967/jnumed.123.266383
Theranostic pair
<a href="/tracers/lu177-dotatate/">lu177-dotatate</a>

Regulatory status

FDA
No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=FET-bAG-TOCA
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
FASTlab
GE HealthCare
vendor cassetteHPLC+SPE6.5% ± 2.9%
no
>98%propanyl-βAG-TOCA
ABX
32252406
2020 Cancers (Basel)
the cassette-based GE FASTLab™ platform — The radiosynthesis produced [18F]FET-βAG-TOCA in 6.5% ± 2.9% RCY (n.d.c) with a molar activity >150 GBq/μmol
FASTlab
GE HealthCare
vendor cassetteHPLC+SPE16.7% ± 0.6%
no
—propanyl-βAG-TOCA
ABX
32252406
2020 Cancers (Basel)
we investigated new automated methodologies to facilitate CuAAC "click" radiochemistry on the GE FASTLab™ platform — the radiolabelling proceeded efficiently with an isolated radiochemical yield (non-decay corrected) of 16.7% ± 0.6%
——————42018345
2026 Clin Exp Rheumatol

Need this precursor?We can point you to suppliers for [18F]FET-bAG-TOCA, or handle the enquiry for you.

Get in touch

Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
—
USP monograph
—
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [18F]FET-bAG-TOCA.

Get in touch