Tracer library / [18F]FET-bAG-TOCA

[18F]FET-bAG-TOCA

Also written as [18F]FET-bAG-TOCA; [F-18]FET-bAG-TOCA; FET-bAG-TOCA; fluoroethyl triazole [Tyr3]octreotate
Radionuclide
F-18 t½ 109.7 min
Modality
PET
Production route
Cyclotron liquid target
Stage
Research
Syntheses indexed
0

What it is

Compound class
Peptide (somatostatin analogue)
Target / mechanism
SSTR2 PMID 32252406 / DOI 10.1021/acs.jmedchem.9b02017
Clinical application
Neuroendocrine tumours PMID 27173162; PMID 38331457 / DOI 10.2967/jnumed.123.266383
Theranostic pair
[177Lu]Lu-DOTATATE

Regulatory status

FDA
No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=FET-bAG-TOCA
EMA (centralised)
—
Other approvals
—
Brand names
—

Published syntheses

No synthesis has been parsed for this agent yet.

Precursor

Common precursor
—
Suppliers seen in the literature
—
Typical final purification
HPLC

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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