Tracers / [177Lu]Lu-CP04
[177Lu]Lu-CP04
Also written as [177Lu]Lu-CP04; [Lu-177]Lu-CP04
- Radionuclide
- Lu-177 t½ 9585 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- DOTA-conjugated minigastrin analogue (CCK-2 receptor-targeting peptide)
- Target / mechanism
- CCK-2 receptor (CCK2R) targeting PMID 41509636
- Clinical application
- CCK2R-targeted radioligand therapy of neuroendocrine tumors (clinical standard agent CP04) PMID 41509636
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | none | >95% | >95% | CP04 | 36558917 2022 Pharmaceuticals (Basel) |
| Manual synthesis | — | HPLC | — | 94% | DOTA-CP04 | 41509636 2026 RSC Adv These DOTA-peptides were subsequently radiolabeled with 177Lu as detailed in the SI materials. |
| — | — | HPLC | — | ≥ 94% | CP04 | 37493526 2023 J Med Chem |
| — | — | HPLC | >90% | — | CP04 | 26315862 2015 Nucl Med Rev Cent East Eur Complex formation needed 5 min in microwave oven or 12 min in thermo-block at 95°C. — Yields of CP04 radiolabelling were greater than 90% for all three radionuclides. |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [177Lu]Lu-CP04.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with Lu-177. Compound class inferred from precursor name (not stated outright) -- PMID 41509636: 'DOTA-CP04'.