Tracer library / [177Lu]Lu-CP04

[177Lu]Lu-CP04

Also written as [177Lu]Lu-CP04; [Lu-177]Lu-CP04

Radionuclide: Lu-177 t½ 9585 min
Modality: Therapy
Production route: —
Stage: —
Syntheses indexed: 4

Neuroendocrine neoplasms Peptide receptor radionuclide therapy

What it is

Compound class: DOTA-conjugated minigastrin analogue (CCK-2 receptor-targeting peptide)
Target / mechanism: CCK-2 receptor (CCK2R) targeting PMID 41509636
Clinical application: CCK2R-targeted radioligand therapy of neuroendocrine tumors (clinical standard agent CP04) PMID 41509636
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	none	>95%	>95%	CP04	36558917 2022 Pharmaceuticals (Basel)
Manual synthesis	—	HPLC	—	94%	DOTA-CP04	41509636 2026 RSC Adv These DOTA-peptides were subsequently radiolabeled with 177Lu as detailed in the SI materials.
—	—	HPLC	—	≥ 94%	CP04	37493526 2023 J Med Chem
Manual synthesis n/a	—	HPLC	>90%	—	CP04	26315862 2015 Nucl Med Rev Cent East Eur Complex formation needed 5 min in microwave oven or 12 min in thermo-block at 95°C. - Yields of CP04 radiolabelling were greater than 90% for all three radionuclides.

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityOsmolalityMolar activityMetal impuritiesLu-177m

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Lu-177. Compound class inferred from precursor name (not stated outright) -- PMID 41509636: 'DOTA-CP04'.