Tracer library / [212Pb]Pb-eSOMA-02

[212Pb]Pb-eSOMA-02

Radionuclide: Pb-212 t½ 638.4 min
Modality: Therapy
Production route: —
Stage: Reported once
Syntheses indexed: 1

Neuroendocrine neoplasms Preclinical only, no clinical indication yet

What it is

Compound class: Somatostatin receptor-targeting peptide (octreotate-based analogue)
Target / mechanism: SSTR2 (somatostatin receptor subtype 2) PMID 37513897
Clinical application: Targeted alpha therapy of neuroendocrine tumors PMID 37513897
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	none	≥96%	≥95%	eSOMA-02	37513897 2023 Pharmaceuticals (Basel) [212Pb]PbCl2 (100 kBq) in 0.1 M HCl ... was added to a mixture of DOTAM-TATE or eSOMA-(01-03) (1 nmol), ascorbic acid/gentisic acid (10 μL, 50 mM), sodium acetate (30 μL, 2.5 M), and H2O (final volume of 140 μL). The mixture was incubated for 20 min at rt. - All labeled compounds were obtained with a RCY ≥ 96% and a RCP ≥ 95%.

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 37513897. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 37513897: 'eSOMA-02'.