Tracers / [123I]MIBG
[123I]MIBG
Also written as I-123 MIBG; I-123-MIBG; MIBG
- Radionuclide
- I-123 t½ 792 min
- Modality
- SPECT
- Production route
- —
- Stage
- —
- Syntheses indexed
- 33
What it is
- Compound class
- radioiodinated benzylguanidine (norepinephrine analogue)
- Target / mechanism
- Norepinephrine transporter-mediated uptake into sympathetic nerve terminals (noradrenergic/adrenergic system imaging) PMID 40262827
- Clinical application
- Diagnostic imaging of cardiac sympathetic innervation and neuroendocrine tumours (pheochromocytoma/paraganglioma, neuroblastoma) using [123I]MIBG SPECT/scintigraphy PMID 34023989
- Theranostic pair
- <a href="/tracers/i131-mibg/">i131-mibg</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | — | — | 42453302 2026 JCEM Case Rep |
| — | — | — | — | — | — | 42405858 2026 Mov Disord Clin Pract |
| — | — | — | — | — | — | 42031675 2026 Brain Behav |
| — | — | — | — | — | — | 41437969 2026 Urol Case Rep |
| — | — | — | — | — | — | 41413609 2025 Cardiovasc Diabetol Endocrinol Rep |
| — | — | — | — | — | — | 41332057 2025 Int J Surg Case Rep |
| — | — | — | — | — | — | 41062315 2026 Intern Med |
| — | — | — | — | — | — | 41026714 2025 PLoS One |
| — | — | — | — | — | — | 40842753 2025 Cureus |
| — | — | — | — | — | — | 40262827 2025 J Nucl Med Technol |
| — | — | — | — | — | — | 40064709 2025 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | — | 39909450 2025 Fukushima J Med Sci |
| — | — | — | — | — | — | 39351526 2024 Front Endocrinol (Lausanne) |
| — | — | — | — | — | — PDR Pharma, Japan | 39294365 2024 Mol Imaging Biol |
| — | — | — | — | — | — | 38848178 2024 J Alzheimers Dis |
| — | — | — | — | — | — | 37629643 2023 Life (Basel) |
| — | — | — | — | — | — | 34414983 2021 Medicine (Baltimore) |
| — | — | — | — | — | — | 34023989 2021 Ann Nucl Med |
| — | — | — | — | — | — | 32134983 2020 PLoS One |
| Manual synthesis | — | — | — | — | — | 9649115 1998 Br J Cancer Using a no-carrier-added synthesis route, we produced 123I-, 125I-, 131I- and 211At-labelled benzylguanidines |
| — | — | — | — | — | — | 38401301 2024 J Neurol Sci |
| — | — | — | — | — | — | 16549383 2006 Parkinsonism Relat Disord |
| — | — | — | — | — | — | 15981676 2005 Ann Nucl Med |
| — | — | — | — | — | — | 11190582 2000 J Cardiol |
| — | — | — | — | — | — | 9666388 1998 J Cardiol |
| — | — | — | — | — | — | 42231758 2026 Nucl Med Commun |
| — | — | — | — | — | — | 42113568 2026 Clin Nucl Med |
| — | — | — | — | — | — | 42003573 2026 Nucl Med Rev Cent East Eur |
| — | — | — | — | — | — | 41949892 2026 Clin Nucl Med |
| — | — | — | — | — | — | 41906292 2026 Hinyokika Kiyo |
| — | — | — | — | — | — | 37160439 2023 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | — | 36435928 2023 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | — | 30167932 2018 J Neural Transm (Vienna) |
Need this precursor?We can point you to suppliers for [123I]MIBG, or handle the enquiry for you.
Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [123I]MIBG.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with I-123. Also seen with I-131[1] (too few articles for own row). | Stage 28: added indication(s) car-sympathetic from consolidated missing-rubric review.