Tracers / [90Y]Y-DOTATATE
[90Y]Y-DOTATATE
Also written as DOTATATE; DOTA-TATE; dotatate
- Radionuclide
- Y-90 t½ 3843.6 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- DOTA-conjugated somatostatin analog
- Target / mechanism
- Somatostatin receptor (SSTR) binding PMID 41356201
- Clinical application
- Peptide receptor radionuclide therapy for SSTR-expressing neuroendocrine neoplasms PMID 41356201
- Theranostic pair
- <a href="/tracers/ga68-dotatate/">ga68-dotatate</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | — | DOTATATE | 41356201 2026 Theranostics |
| — | — | — | — | more than 97% | DOTATATE | 26443981 2016 Nucl Med Commun novel, self-shielded modular radiosynthesis system for fully automated preparation of PET and therapeutic radiopharmaceuticals |
| — | — | — | — | — | — | 32293704 2020 Endokrynol Pol |
| — | — | — | — | >95% | DOTA-TATE | 30770227 2019 Nucl Med Biol A two-step radiochemical separation procedure based on selective precipitation of 90Y under alkaline conditions from 90Sr/90Y equilibrium mixture was developed. |
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Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 8 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Diagnostic pair signal at discovery: YES - Cu-64, Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 41356201: 'The DOTA-conjugated somatostatin analogs DOTATOC and DOTATATE were labeled with 68Ga for SSTR PET imaging and either 177Lu or 90Y for IA-PRRT'.