Tracers / [161Tb]Tb-DOTA-TOC
[161Tb]Tb-DOTA-TOC
Also written as DOTATOC; DOTA-TOC
- Radionuclide
- Tb-161 t½ 9907.2 min
- Modality
- Therapy
- Production route
- —
- Stage
- preclinical study
- Syntheses indexed
- 1
What it is
- Compound class
- DOTATOC (somatostatin receptor agonist peptide)
- Target / mechanism
- Somatostatin receptor (SSTR) agonist PMID 34625828
- Clinical application
- Treatment of neuroendocrine neoplasms (preclinical study) PMID 34625828
- Theranostic pair
- <a href="/tracers/ga68-dotatoc/">ga68-dotatoc</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | ≥ 98% | DOTATOC | 34625828 2022 Eur J Nucl Med Mol Imaging |
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Get in touchNotes
Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Diagnostic pair signal at discovery: YES - Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 34625828: 'DOTATOC'. Stage set/updated at stage 23 from PMID 34625828: 'Based on these preclinical data, [161Tb]Tb-DOTA-LM3 may outperform the clinically employed [177Lu]Lu-DOTATOC for the treatment of patients with NENs.'.