Tracers / [18F]FETrp
[18F]FETrp
Also written as [18F]FETrp; [F-18]FETrp; F-18 FETrp; FETrp; fluoroethyltryptophan
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Research
- Syntheses indexed
- 5
What it is
- Compound class
- Amino acid
- Target / mechanism
- Amino-acid transporters and the IDO-mediated kynurenine pathway of tryptophan metabolism PMID 30815792 / DOI 10.1007/s11307-019-01327-4
- Clinical application
- PET imaging of cancer via dual targeting of amino-acid transporters and the IDO/kynurenine tryptophan-metabolism pathway (brain tumours, neuroendocrine tumours; preclinical + patient studies) PMID 30815792 / DOI 10.1007/s11307-019-01327-4; PMID 38012510 / DOI 10.1007/s11307-023-01877-8
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=fluoroethyltryptophan
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- 5.2 MBq/kg (0.14 mCi/kg) in patients PMID 38012510 / DOI 10.1007/s11307-023-01877-8
- Uptake time
- Dynamic imaging from injection; brain-tumour SUV peaks ~90 min p.i.; whole-body multi-pass scans 0-60 min PMID 38012510 / DOI 10.1007/s11307-023-01877-8; PMID 32123231 / DOI 10.1038/s41598-020-60728-6
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Synthra RNplus Synthra | custom manifold | HPLC+SPE | 6.0 ± 0.3% yes | 96–97% | tert-Butyl Nα-(tert-butoxycarbonyl)-1-(2-(tosyloxy)ethyl)-L-tryptophanate Affinity Research Chemical Inc, Wilmington, DE, USA | 37118900 2023 J Labelled Comp Radiopharm Synthra RNPlus research module — The radiochemical yields were 6.0 ± 0.3% (decay corrected to EOB). |
| Raytest SynChrom Elysia-Raytest | custom manifold | HPLC+SPE | 55.2 ± 7.5% yes | 99.9% | (S)-3 tosylate precursor | 38564046 2024 EJNMMI Radiopharm Chem fully automated on a SynChrom R&D EVOI module — to produce the radiotracer in 55.2 ± 7.5% radiochemical yield |
| — | — | — | 19.0 ± 7.0 yes | over 99 % | N-boc-1-(2-tosylethyl) tryptophan tert-butyl ester | 27815661 2017 Mol Imaging Biol in a GE Tracerlab FX-N module — 19.0 ± 7.0 and 9.0 ± 3.0 % (n = 3) decay-corrected yield |
| — | — | — | 9.0 ± 3.0 yes | over 99 % | N-boc-1-(2-tosylethyl) tryptophan tert-butyl ester | 27815661 2017 Mol Imaging Biol in a GE Tracerlab FX-N module — 19.0 ± 7.0 and 9.0 ± 3.0 % (n = 3) decay-corrected yield |
| — | — | — | about 12% no | above 95% | 1,3-di(4-methylphenylsulfonyloxy)propane | 12798378 2003 Appl Radiat Isot |
Precursor
- Common precursor
- (S)-tert-butyl 2-((tert-butoxycarbonyl)amino)-3-(1-(2-(tosyloxy)ethyl)-1H-indol-3-yl)propanoate (Boc/tBu-protected 1-(2-tosyloxyethyl)indole precursor) PMID 32123231 / DOI 10.1038/s41598-020-60728-6
- Suppliers seen in the literature
- Affinity Research Chemicals Inc (Wilmington, DE, USA)
- Cited suppliers in indexed syntheses
- Affinity Research Chemical Inc
- Typical final purification
- HPLC
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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