Tracers / [177Lu]Lu-HA-DOTATATE
[177Lu]Lu-HA-DOTATATE
Also written as [Lu-177]Lu-HA-DOTATATE; Lu-177-HA-DOTATATE
- Radionuclide
- Lu-177 t½ 9584.6 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- DOTATATE peptide analogue (somatostatin analogue) - HA-DOTA-TATE precursor
- Target / mechanism
- —
- Clinical application
- Peptide Receptor Radionuclide Therapy (PRRT) for neuroendocrine tumors PMID 40361351
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Modular-Lab PharmTracer Eckert & Ziegler | vendor cassette | SPE | — | — | HA-DOTA-TATE piCHEM, Raaba-Grambach, Austria | 27090254 2016 EJNMMI Res 177Lu-radiolabelling was performed using the cassette-based ModularLab PharmTracer® synthesizer (EZAG, Berlin, Germany) |
| Manual synthesis | — | none | — | >98% | HA-DOTATATE Scintomics, Fürstenfeldbruck, Germany | 40361351 2025 Cancers (Basel) The precursor HA-DOTATATE (80 nmol or 125 μg) dissolved in 0.4 M sodium-acetate buffer (pH 4.5, 1.5 mL) was directly added to the 177Lu-vial (7.6 GBq 177Lu in approx. 200 µL 0.04 M HCl) and the mixture was heated for 20 min at 95 °C. |
| Modular-Lab PharmTracer Eckert & Ziegler | vendor cassette | SPE | — | — | HA-DOTA-TATE piCHEM, Raaba-Grambach, Austria | 27090254 2016 EJNMMI Res 177Lu-radiolabelling was performed using the cassette-based ModularLab PharmTracer® synthesizer (EZAG, Berlin, Germany) |
| — | — | — | — | — | — | 41857356 2026 Eur J Nucl Med Mol Imaging |
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Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 3 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 27090254: 'HA-DOTA-TATE (PiChem, Graz, Austria)'.