Tracer library / [18F]AmBF3-TATE

[18F]AmBF3-TATE

Also written as [18F]AMBF3-TATE; [F-18]AMBF3-TATE

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 3

Neuroendocrine neoplasms Dosimetry and biodistribution studies

What it is

Compound class: octreotate-based somatostatin analog peptide labeled via organotrifluoroborate (AmBF3) 18F-labeling
Target / mechanism: Somatostatin receptor subtype 2 (SSTR2) agonist binding PMID 32189151
Clinical application: PET imaging of somatostatin receptor-expressing neuroendocrine tumors, potential alternative to [68Ga]Ga-DOTATATE PMID 29747035
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
In-house / custom built	custom manifold	SPE	16±1% decay-corrected	>99%	AMBF3-TATE precursor (TATE-AMBF3)	29747035 2018 Nucl Med Biol The radiosynthesis was performed in droplets on microfluidic chips composed of Teflon-coated glass substrates. - overall decay-corrected radiochemical yield of 16±1% (n=5) in ~40 min
ELIXYS FLEX/CHEM Sofie	—	SPE	16±1% decay-corrected	>99%	AMBF3-TATE precursor (TATE-AMBF3)	29747035 2018 Nucl Med Biol using an ELIXYS FLEX/CHEM radiosynthesizer, Sofie Biosciences, Inc., Culver City, CA, USA - overall decay-corrected radiochemical yield of 16±1% (n=5) in ~40 min
AllinOne (AiO) Trasis	vendor cassette	HPLC+SPE	15 ± 4% decay-corrected	98.0 ± 1.73%	[19F]AmBF3-TATE precursor AmbioPharm Inc.	32189151 2020 EJNMMI Res Production of [18F]AmBF3-TATE was conducted on a Trasis AllInOne module with 36 manifold actuators and an integrated HPLC system - decay corrected radiochemical yields of 15 ± 4%

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: AmbioPharm Inc.
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 29747035: 'AMBF3-TATE precursor (TATE-AMBF3)'. Stage set/updated at stage 23 from PMID 29747035: 'we performed microfluidic labeling of an octreotate analog ([18F]AMBF3-TATE)'.