Tracer library / [89Zr]Zr-TROP2

[89Zr]Zr-TROP2

Also written as [89Zr]TROP2; [Zr-89]TROP2

Radionuclide: Zr-89 t½ 4704 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Gynaecological cancer Preclinical only, no clinical indication yet

What it is

Compound class: 89Zr-labeled anti-Trop2 antibody (immunoPET tracer, DFO-conjugated)
Target / mechanism: Trophoblast cell surface antigen 2 (TROP-2) PMID 41760827
Clinical application: High grade serous ovarian cancer PMID 41760827
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Mortenon M1 vendor not confirmed -- see article	—	—	82.31% ± 3.92%	>99%	—	38145430 2024 Ann Nucl Med full-automatic cassette-based synthesis module system Mortenon M1 for synthesis of radiopharmaceuticals - [89Zr]-TROP2, 82.31% ± 3.92%, n = 10

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impurities

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with Zr-89.