Tracers / [89Zr]Zr-TROP2

[89Zr]Zr-TROP2

Also written as [89Zr]TROP2; [Zr-89]TROP2
Radionuclide
Zr-89 t½ 4704 min
Modality
PET
Production route
—
Stage
preclinical
Syntheses indexed
1
Gynaecological cancerPreclinical only, no clinical indication yet

What it is

Compound class
89Zr-labeled anti-Trop2 antibody (immunoPET tracer, DFO-conjugated)
Target / mechanism
Trophoblast cell surface antigen 2 (TROP-2) PMID 41760827
Clinical application
High grade serous ovarian cancer PMID 41760827
Theranostic pair
—

Regulatory status

FDA
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EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
———82.31% ± 3.92%above 99%—38145430
2024 Ann Nucl Med
full-automatic cassette-based synthesis module system Mortenon M1 for synthesis of radiopharmaceuticals — [89Zr]-TROP2, 82.31% ± 3.92%, n = 10

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impurities
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with Zr-89.