Tracers / [18F]FCPPC
[18F]FCPPC
Also written as [18F]FCPPC
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- CSF1R-targeting radiotracer (CPPC derivative)
- Target / mechanism
- Colony-stimulating factor 1 receptor (CSF1R), expressed on microglia PMID 39840376
- Clinical application
- PET imaging of microglia density as a biomarker of neuroinflammation PMID 39840376
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Synthra RNplus | — | — | 26.8 ± 0.1% yes | >99% | — | 39840376 2024 Am J Nucl Med Mol Imaging a fully automated radiosynthesis of [18F]FCPPC on a Synthra RNplus research module — [18F]FCPPC was obtained in decay corrected radiochemical yields of 26.8 ± 0.1% (n = 3) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FCPPC.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18.