Tracer library / [18F]FPG-IL4
[18F]FPG-IL4
Also written as [18F]FPG-IL4; [F-18]FPG-IL4
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- Radiolabelled protein (interleukin-4, IL-4) conjugated via arginine-selective bioconjugation with 4-[18F]fluorophenylglyoxal
- Target / mechanism
- Interleukin-4 receptor (IL-4R) on activated T cells PMID 40454025
- Clinical application
- —
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Scintomics GRP 4V Scintomics | custom manifold | SPE | 26 ± 2% not corrected | >99% | [18F]FPG | 40454025 2025 ACS Omega we equipped the Scintomics GRP4 V synthesis module with the single-use, DMSO-resistant hardware kits - [18F]FPG-IL-4 was obtained in 26 ± 2% n.d.c. RCYs (n = 3) from [18F]FPG |
Need this precursor?We can point you to suppliers for [18F]FPG-IL4, or handle the enquiry for you.
Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FPG-IL4.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 40454025: 'human IL-4 (13 nmol)'. Stage set/updated at stage 39 from PMID 40454025: 'The in vivo biodistribution and pharmacokinetics of [18F]-FPG-IL4 were evaluated in healthy Balb/c mice with PET imaging.'.