Tracer library / [18F]MEL050

[18F]MEL050

Also written as [18F]MEL050; [F-18]MEL050
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
Clinical research
Syntheses indexed
1
MelanomaDosimetry and biodistribution studiesRadiochemistry methodologyPreclinical only, no clinical indication yet

What it is

Compound class
benzamide-derived melanin-binding radiofluorinated nicotinamide (pyridine-3-carboxamide) PET tracer
Target / mechanism
Melanin PMID 40537707
Clinical application
Metastatic melanoma PMID 40537707
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
AllinOne (AiO)
Trasis
—HPLC13-18%
not corrected
>99%—27693672
2016 Nucl Med Biol
were performed on an AllInOne™ synthesis module - with a yield of 13-18% (not-decay corrected)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. | Stage 30 (2026-09-18): Stage was 'phase I'; normalised to 'Clinical research', original wording kept here.
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