Tracers / [18F]SqFLT
[18F]SqFLT
Also written as 3'-[18F]fluorothymidine-5'-squaryl; [18F]SqFLT; [F-18]SqFLT
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Research
- Syntheses indexed
- 0
What it is
- Compound class
- —
- Target / mechanism
- Thymidylate kinase (TMPK) - bioisostere of [18F]FLT-5'-monophosphate designed to image TMPK activity downstream of, and independent of, thymidine kinase 1 (TK1); enters cells by passive diffusion (not via nucleoside transporters) PMID 35423725 / DOI 10.1039/d1ra00205h
- Clinical application
- (preclinical only) intended as a TK1-independent PET proliferation marker; in the reported evaluation it lacked tumour retention and behaved more as a TMPK antagonist than a substrate, so judged unsuitable for proliferation imaging in its current form PMID 35423725 / DOI 10.1039/d1ra00205h
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=SqFLT+fluorothymidine+squaryl
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
No synthesis has been parsed for this agent yet.
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]SqFLT.
Get in touchNotes
Target and application not filled - to be taken from the publication.