Tracers / [18F]BPAM121

[18F]BPAM121

Also written as [18F]BPAM121; [F-18]BPAM121; BPAM121
Radionuclide
F-18 t½ 109.7 min
Modality
PET
Production route
Cyclotron liquid target
Stage
Research
Syntheses indexed
1
CNS receptor and transporter imagingAlzheimer's diseasePreclinical only, no clinical indication yet

What it is

Compound class
—
Target / mechanism
AMPA receptor (ionotropic glutamate receptor) positive allosteric modulator PMID 30740927 / DOI 10.1002/cmdc.201800816
Clinical application
(preclinical only) proposed PET radiotracer for imaging AMPA receptors in Alzheimer's disease; evaluated in mice PMID 30740927 / DOI 10.1002/cmdc.201800816
Theranostic pair
—

Regulatory status

FDA
No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=BPAM121
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
—————tosylated precursor30740927
2019 ChemMedChem
using a commercial FASTlab synthesizer from GE Healthcare

Precursor

Common precursor
Tosylated precursor (nucleophilic [18F]fluorination); synthetic procedure reported in the source PMID 30740927 / DOI 10.1002/cmdc.201800816
Suppliers seen in the literature
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Typical final purification
HPLC

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Target and application not filled - to be taken from the publication.