Tracer library / [177Lu]Lu-DOTA-rhCCK-18

[177Lu]Lu-DOTA-rhCCK-18

Also written as [177Lu]Lu-DOTA-rhCCK-18; [Lu-177]Lu-DOTA-rhCCK-18

Radionuclide: Lu-177 t½ 9585 min
Modality: Therapy
Production route: —
Stage: —
Syntheses indexed: 1

Preclinical only, no clinical indication yet

What it is

Compound class: DOTA-conjugated minigastrin/CCK-2R-targeting peptide (radiohybrid)
Target / mechanism: CCK-2 receptor (CCK-2R) targeting PMID 36986687
Clinical application: —
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	custom manifold	none	quantitative	quantitative	DOTA-rhCCK-18	36986687 2023 Pharmaceutics

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityOsmolalityMolar activityMetal impuritiesLu-177m

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with Lu-177. Compound class inferred from precursor name (not stated outright) -- PMID 36986687: 'DOTA-rhCCK-18'.