Tracer library / [18F]FG-CP31398
[18F]FG-CP31398
Also written as [18F]FG-CP31398; [F-18]FG-CP31398
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- Fluorine-18 labeled small-molecule derivative of CP31398 (styrylquinazoline-type p53-targeting compound)
- Target / mechanism
- Mutant/wild-type protein p53 (intended target; actual binding to an unidentified target) PMID 41696278
- Clinical application
- Cancer imaging via mutant p53 expression, using human lung cancer tumor cell lines/tissue as models PMID 41696278
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — Trasis | — | HPLC+SPE | 10 ± 4 | 96% | tosylate precursor 3 | 41696278 2026 ACS Omega the whole radiosynthesis process was automated on the Trasis AllinOne synthesizer - [18F]FG-CP31398 (2.3 ± 0.5 GBq) in 10 ± 4% RCY (n = 4) within 45 min |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FG-CP31398.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. Stage set/updated at stage 39 from PMID 41696278: 'Binding experiments performed with [18F]FG-CP31398 on HEK-293T cells transfected with a green fluorescent protein-p53 wild-type plasmid'.