Tracers / [18F]FG-CP31398

[18F]FG-CP31398

Also written as [18F]FG-CP31398; [F-18]FG-CP31398

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Preclinical only, no clinical indication yet

What it is

Compound class: Fluorine-18 labeled small-molecule derivative of CP31398 (styrylquinazoline-type p53-targeting compound)
Target / mechanism: —
Clinical application: —
Theranostic pair: —

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
— Trasis	—	HPLC+SPE	10 ± 4	96%	tosylate precursor 3	41696278 2026 ACS Omega the whole radiosynthesis process was automated on the Trasis AllinOne synthesizer — [18F]FG-CP31398 (2.3 ± 0.5 GBq) in 10 ± 4% RCY (n = 4) within 45 min

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.