Tracer library / [111In]eFAP-6

[111In]eFAP-6

Also written as [In-111]In-eFAP-6

Radionuclide: In-111 t½ 4031.6 min
Modality: SPECT
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Preclinical only, no clinical indication yet Fibroblast activation / tumour stroma

What it is

Compound class: FAP-targeting small molecule (DOTA-conjugated quinoline-based FAP inhibitor)
Target / mechanism: Fibroblast activation protein (FAP) PMID 39073475
Clinical application: Solid tumors with FAP-expressing cancer-associated fibroblasts in the tumor stroma; potential for radionuclide theranostics and fluorescent-guided surgery PMID 39073475
Theranostic pair: [177Lu]Lu-eFAP-6

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	—	>95%	>95%	eFAP-6	39073475 2024 EJNMMI Radiopharm Chem Labeling reactions were performed in a solution containing sodium acetate (1 µL, 2.5 M), ascorbic and gentisic acids (10 µL, 50 mM), ethanol (10 µL), and complemented with Milli-Q water. - Radiolabeling of eFAP-6 with 111-indium and 177-lutetium was performed successfully with high radiochemical yield and purity (> 95%).

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 39073475. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 39073475: 'eFAP-6 (1 nmol), 50 MBq [111In]InCl3'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to SPECT: In-111 agent whose theranostic partner lu177-efap6 carries the therapy isotope Lu-177: this is the imaging half of the pair. Linked articles: PMID 39073475. Stage set/updated at stage 39 from PMID 39073475: 'Studies with HT1080-huFAP xenografted mice confirmed a more rapid uptake of [177Lu]Lu-eFAP-6 vs. [177Lu]Lu-FAPI-46.'.