Tracer library / [188Re]Re-188-HYNIC-BBN

[188Re]Re-188-HYNIC-BBN

Also written as Re-188-HYNIC-BBN; Re-188-HYNICBBN

Radionuclide: Re-188 t½ 1020 min
Modality: Therapy
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Radiochemistry methodology Preclinical only, no clinical indication yet

What it is

Compound class: HYNIC-conjugated bombesin peptide analogue
Target / mechanism: Gastrin-releasing peptide receptor (GRPR) PMID 39036461
Clinical application: Targeted radionuclide therapy for GRPR-positive prostate cancer PMID 36121093
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	—	—	> 95%	HYNIC-BBN	39036461 2024 Nucl Med Mol Imaging

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 39036461: 'HYNIC-BBN'. Stage set/updated at stage 39 from PMID 36121093: 'its radiation absorbed dose of the adult human was calculated for different organs based on the MIRD dose calculation method'.