Tracer library / [161Tb]Tb-pepa-pic2-C-Hex-KuE
[161Tb]Tb-pepa-pic2-C-Hex-KuE
Also written as [Tb-161]Tb-pepa-pic2-C-Hex-KuE
- Radionuclide
- Tb-161 t½ 9907.2 min
- Modality
- Therapy
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- PSMA-targeting urea-based small molecule (C-Hex-KuE) conjugated to pepa-pic2 rare-earth chelator
- Target / mechanism
- Prostate-specific membrane antigen (PSMA) PMID 41324598
- Clinical application
- Prostate cancer theranostics (PSMA-targeted imaging and radiotherapy) PMID 41324598
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | — | — | pepa-pic2-C-Hex-KuE | 41324598 2025 J Am Chem Soc The formation of [177Lu]Lu-pepa-pic2-C-Hex-KuE and [161Tb]Tb-pepa-pic2-C-Hex-KuE was achieved under identical reaction conditions as previously employed for the 86Y analogue (80 °C, pH 5.5) |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41324598. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41324598: 'pepa-pic2-C-Hex-KuE'. Stage set/updated at stage 39 from PMID 41324598: 'in vivo studies with [177Lu]Lu-pepa-pic2-C-Hex-KuE and [161Tb]Tb-pepa-pic2-C-Hex-KuE evidence efficient tumor uptake of β- radiotherapeutics'.