Tracer library / [11C]L-glutamine

Structure of L-glutamine (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 5961

[11C]L-glutamine

Also written as [11C]L-Glutamine; [C-11]L-Glutamine

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

Radiochemistry methodology Preclinical only, no clinical indication yet

What it is

Compound class: Radiolabelled natural amino acid (L-glutamine analogue)
Target / mechanism: Glutamine utilization/transport as carbon source for cancer cell metabolism (glutaminolysis) PMID 30359787
Clinical application: PET imaging of glutamine metabolism (glutaminolysis) in cancer, including triple negative breast cancer (TNBC) PMID 31659517
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Synthra HCNplus Synthra	custom manifold	HPLC+SPE	43-52% decay-corrected	>90%	(S)-tert-butyl-2-((tert-butoxycarbonyl)amino…(S)-tert-butyl-2-((tert-butoxycarbonyl)amino)-4-iodobutanoate ABX	31659517 2019 EJNMMI Radiopharm Chem Synthra HCN Plus automated synthesis module - The decay corrected yield from the [11C] cyanide trapping into the reaction vessel was 43–52% (n = 4).
TRACERlab FX2 N GE HealthCare	custom manifold	HPLC+SPE	>70% decay corrected; 15% non-decay-corrected decay-corrected	>99%	(S)Tert-Butyl 2-((tert-butoxycarbonyl)…(S)Tert-Butyl 2-((tert-butoxycarbonyl) amino)-4-Iodobutanoate Advanced Biochemical Compounds, ABX, Germany	30359787 2018 Nucl Med Biol The preparation of [11C]Gln was carried out on the the GE FX2N platform. - the radiochemical yield was significantly improved to over 70% decay corrected and to 15% non-decay-corrected (based upon the [11C]HCN trapped)

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: ABX, Advanced Biochemical Compounds
Typical final purification: —

Need this precursor?We can point you to suppliers for [11C]L-glutamine, or handle the enquiry for you.

Get in touch

Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC cond.Radionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [11C]L-glutamine.

Get in touch

Notes

Added from reverse module search (stage 6); 2 article(s) with C-11.