Tracers / [11C]L-glutamine

[11C]L-glutamine

Also written as [11C]L-Glutamine; [C-11]L-Glutamine
Radionuclide
C-11 t½ 20.36 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
2
Radiochemistry methodologyPreclinical only, no clinical indication yet

What it is

Compound class
Radiolabelled natural amino acid (L-glutamine analogue)
Target / mechanism
Glutamine utilization/transport as carbon source for cancer cell metabolism (glutaminolysis) PMID 30359787
Clinical application
PET imaging of glutamine metabolism (glutaminolysis) in cancer, including triple negative breast cancer (TNBC) PMID 31659517
Theranostic pair
—

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
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Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Synthra HCNplus
Synthra
custom manifoldHPLC+SPE43-52%
yes
>90%(S)-tert-butyl-2-((tert-butoxycarbonyl)amino)-4-iodobutanoate
ABX
31659517
2019 EJNMMI Radiopharm Chem
Synthra HCN Plus automated synthesis module — The decay corrected yield from the [11C] cyanide trapping into the reaction vessel was 43–52% (n = 4).
TRACERlab FX2 N
GE HealthCare
custom manifoldHPLC+SPE>70% decay corrected; 15% non-decay-corrected
yes
>99%(S)Tert-Butyl 2-((tert-butoxycarbonyl) amino)-4-Iodobutanoate
Advanced Biochemical Compounds, ABX, Germany
30359787
2018 Nucl Med Biol
The preparation of [11C]Gln was carried out on the the GE FX2N platform. — the radiochemical yield was significantly improved to over 70% decay corrected and to 15% non-decay-corrected (based upon the [11C]HCN trapped)

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC cond.Radionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with C-11.