Tracers / [68Ga]TacBOMB3
[68Ga]TacBOMB3
Also written as [Ga-68]Ga-TacBOMB3
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- Therapy
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- DOTA-conjugated bombesin(7-14) analog peptide
- Target / mechanism
- GRPR agonist PMID 36838968
- Clinical application
- Detection of GRPR-expressing tumors (PC-3 prostate cancer xenografts) by PET imaging PMID 36838968
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | HPLC+SPE | 51-80% yes | >95% | DOTA-conjugated TacBOMB3 | 36838968 2023 Molecules Purified 68GaCl3 in 0.5 mL of water was added to a 4 mL glass vial preloaded with 0.7 mL of HEPES buffer (2 M, pH 5.0) and 10 μL of precursor solution (1 mM). The radiolabeling reaction was carried out under microwave heating for 1 min before being purified by HPLC using the semi-preparative column. — 68Ga-labeled TacBOMB2, TacBOMB3, and AMBA were obtained in 51–80% decay-corrected radiochemical yields |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 36838968. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 36838968: 'DOTA-conjugated TacBOMB2, TacBOMB3, and TacBOMB4 were obtained in 30–55% yields'.